II. Definitions

  1. Synovial Sarcoma
    1. Slow growing, malignant lesion originating in the joints and synovial cells of tendons and bones
    2. Most often affects the legs (but can also involve abdominal wall and other torso Muscles)

III. Epidemiology

  1. Peak onset age 30 to 40 years old

IV. Findings

  1. Slow growing lesion, typically on the legs or trunk, from 3 to 10 cm in diameter

V. Imaging

  1. XRay
    1. Calcifications may be present (33% of cases)
    2. Bony erosions in up to 20% of cases
  2. Ultrasound
    1. Heterogeneous mass with interspersed necrosis
  3. MRI
    1. Well demarcated mass with similar isointensity to Muscle on T1

VI. Management

  1. Refer for core needle biopsy and surgical resection

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Ontology: synovial sarcoma (C0039101)

Definition (NCI_NCI-GLOSS) A malignant tumor that develops in the synovial membrane of the joints.
Definition (NCI) A malignant neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It can occur at any age, but mainly affects young adults, more commonly males. Although any site can be affected, the vast majority of the cases arise in the deep soft tissues of extremities, especially around the knee. Microscopically, synovial sarcoma is classified as monophasic (with a spindle or epithelial cell component) or biphasic (with both spindle and epithelial cell components). Synovial sarcomas can recur or metastasize to the lungs, bones, and lymph nodes.
Definition (NCI_CDISC) A malignant neoplasm that usually arises in the synovial membranes of the joints and the synovial cells of the tendons and bursae.
Definition (MSH) A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
Concepts Neoplastic Process (T191)
MSH D013584
ICD10 M9040/3
SnomedCT 63211008, 302851001
English Synovioma, Synoviomas, Sarcoma, Synovial, Sarcomas, Synovial, Synovial Sarcomas, [M]Synovial sarcoma NOS, [M]Synovioma NOS, Synovial sarcoma NOS, Synovioma NOS, synovial sarcoma (diagnosis), synovial sarcoma of soft tissue, synovioma of joint (diagnosis), synovial sarcoma of soft tissue (diagnosis), synovioma of joint, synovioma, SARCOMA, SYNOVIAL, Sarcoma, Synovial [Disease/Finding], sarcoma synovial, SS, SARCOMA, SYNOVIAL, MALIGNANT, Synovial sarcoma, Synovioma, malignant, Malignant synovioma, Synovial sarcoma (disorder), Synovial sarcoma (morphologic abnormality), Synovial sarcoma, NOS, Synovioma, NOS, Synovial Sarcoma, synovial sarcoma
Dutch synoviaal sarcoom NAO, synovioom, synoviaal sarcoom, Sarcoom, synoviaal, Sarcoom, synovio-, Synovioom, Synoviosarcoom
French Synovialosarcome SAI, Sarcome synovial, Synovialome, Synovialome malin, Synovialosarcome, Synoviosarcome, Synoviome
German Synovialsarkom NNB, Synoviom, Synovialsarkom, Sarkom, synoviales, Synovialom
Italian Sarcoma sinoviale NAS, Sinovioma, Sarcoma sinoviale
Portuguese Sarcoma sinovial NE, Sarcoma sinovial, Sarcoma Sinovial, Sinovioma
Spanish Sarcoma sinovial NEOM, sarcoma sinovial (anomalía morfológica), sarcoma sinovial (trastorno), sarcoma sinovial, SAI, sarcoma sinovial, sinovioma maligno, sinovioma, SAI, sinovioma, Sarcoma sinovial, Sarcoma Sinovial, Sinovioma
Japanese 滑膜肉腫NOS, カツマクニクシュNOS, カツマクニクシュ, カツマクシュ, 滑膜腫, 滑膜肉腫, 腱滑膜肉腫, 肉腫-滑膜
Swedish Sarkom, synovialt
Czech synoviom, Synoviální sarkom NOS, Synoviální sarkom, Synoviom, synovialom, synovialosarkom, synoviální sarkom
Finnish Synoviaalisarkooma
Polish Maziówczak, Mięsak maziowy
Hungarian Synovialis sarcoma, Synovioma, Synovialis sarcoma k.m.n.
Norwegian Synovialt sarkom