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Ontology:
Antithrombins
(C0003440)
Definition (MSH)
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Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
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Definition (CSP)
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endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin; includes fibrin and antithrombin III.
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Concepts |
Pharmacologic Substance
(T121)
, Biologically Active Substance
(T123)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
D000991
|
SnomedCT |
259742007, 414010005 |
LNC |
LP175677-6 |
English |
Antithrombins, Thrombin Inhibitors, Direct, Direct Antithrombins, Direct Thrombin Inhibitors, Antithrombins, Direct, antithrombin, antithrombins, Antithrombin Proteins, Antithrombin Proteins [Chemical/Ingredient], Direct thrombin inhibitors, Antithrombin, Antithrombin (substance), DTI - direct thrombin inhibitor, Direct thrombin inhibitor (substance), Direct thrombin inhibitor |
French |
Antithrombines, Antithrombiniques directs, Inhibiteurs directs de la thrombine, Anti-thrombines, Antithrombines directes, Antithrombiniques, Anti-thrombiniques |
German |
Direkte Thrombin-Inhibitoren, Direkte Antithrombine, Antithrombine, Direkte Thrombininhibitoren |
Czech |
antithrombiny, přímé inhibitory thrombinu |
Italian |
Antitrombine
|
Spanish |
Antitrombinas Directas, Antitrombinas, antitrombina (sustancia), antitrombina, inhibidor directo de trombina (sustancia), inhibidor directo de trombina |
Russian |
ANTITROMBINY, АНТИТРОМБИНЫ |
Portuguese |
Antitrombinas, Antitrombinas Diretas |
Polish |
Antytrombiny
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Ontology:
argatroban
(C0048470)
Definition (NCI)
|
A synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions, which include conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots and coagulation is inhibited.
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Concepts |
Amino Acid, Peptide, or Protein
(T116)
, Pharmacologic Substance
(T121)
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MSH |
C031942
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SnomedCT |
116508003, 398738008 |
LNC |
LP94569-8, MTHU032477 |
English |
2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-, 4-methyl-1-(N(2)-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl)-2-piperidinecarboxylic acid, MMTQAP, MPQA, 1-[5-guanidino-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid, ARGATROBAN, Argatroban (medication), argatroban [Chemical/Ingredient], Argatroban, Argatroban (product), Argatroban (substance), Argipidine, argatroban |
Spanish |
argatrobano (sustancia), argatroban, argatroban (producto), argatrobán (producto), argatroban (sustancia), argatrobán, argatrobano |
Ontology:
bivalirudin
(C0168273)
Definition (NCI)
|
A 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina.
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Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
|
MSH |
C074619
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SnomedCT |
400610005, 129498009 |
LNC |
LP171388-4 |
English |
Phe-Pro-Arg-Pro-(Gly)4 desulfato-Tyr63'-hirugen, Phe-Pro-Arg-Pro-(Gly)4-desulfohirudin-(53-64), L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-, Phe-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu, bivalirudin, bivalirudin (medication), BIVALIRUDIN, bivalirudin [Chemical/Ingredient], Bivalirudin (product), Bivalirudin (substance), Bivalirudin |
Spanish |
bivalirrudina, bivalirudina (producto), bivalirudina, bivalirrudina (sustancia), bivalirudina (sustancia) |
Ontology:
desirudin
(C0378366)
Definition (NCI)
|
A synthetic recombinant form of the naturally occurring hirudin, the anticoagulant substance found in leech. Desirudin is a selective and almost irreversible inhibitor of thrombin, both free and clot-bound, by blocking its active site. This anticoagulant agent has no effect on other components of the hemostatic system. Desirudin is particularly used to prevent deep vein thrombosis in patients undergoing hip and knee replacement surgery.
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Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
C060225
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SnomedCT |
319718008, 407117009 |
English |
desulfatohirudin, desulphatohirudin, recombinant HV1 hirudin, desirudin, 63-Desulfohirudin(Hirudo medicinalis isoform HV1), desirudin (medication), DESIRUDIN, desirudine, Desirudin (product), Desirudin, Desirudin (substance), Desirudine, Desulfatohirudin |
Spanish |
desirudina (producto), desirudina, desirudina (sustancia), desirudin |
Ontology:
Refludan
(C0661608)
Concepts |
Organic Chemical
(T109)
, Pharmacologic Substance
(T121)
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MSH |
C083544
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English |
Refludan, lepirudin (Refludan), refludan, Hoechst Brand of Lepirudin, Aventis Behring Brand of Lepirudin, Aventis Brand Lepirudin, Aventis Pharma Brand of Lepirudin, Berlex Brand of Lepirudin, Pharmion Brand of Lepirudin, Refludin, Schering Brand of Lepirudin |
Ontology:
lepirudin
(C0772394)
Definition (NCI_NCI-GLOSS)
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A drug that inhibits blood clotting. It is being studied in cancer treatment.
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Definition (NCI)
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A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis.
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Definition (PDQ)
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A recombinant hirudin, a polypeptide naturally produced by the leech Hirudo medicinalis, derived from yeast cells and a highly specific inhibitor of thrombin. Lepirudin directly binds to thrombin, thereby inactivating the thrombogenic activity of thrombin. This anticoagulant produces dose-dependent increases in activated partial thromboplastin time (aPTT). Its action is independent of antithrombin III and it is not inhibited by platelet factor 4. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43356&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43356&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1839" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
|
MSH |
C083544
|
SnomedCT |
108995001, 386955005 |
LNC |
LP171615-0 |
English |
Recombinant Hirudin, 1-Leu-2-Thr-63-desulfohirudin, lepirudin, lepirudin (medication), lepirudin (rDNA), LEPIRUDIN, lepirudin [Chemical/Ingredient], lepirudin,recombinant, Lepirudin, Lepirudin (product), Lepirudin (substance) |
Spanish |
lepirudina (producto), lepirudina (sustancia), lepirudina |
Ontology:
Acova
(C0939245)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C031942
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English |
Acova, SmithKline Beecham brand of argatroban |
Ontology:
Angiomax
(C0939677)
Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
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MSH |
C074619
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English |
Angiomax, The Medicines Company brand of bivalirudin |
Ontology:
Hirudins
(C1451270)
Definition (MSH)
|
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
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Definition (CSP)
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active principle in the buccal gland secretion (saliva) of leeches; it acts as an antithrombin and as an antithrombotic agent.
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Concepts |
Amino Acid, Peptide, or Protein
(T116)
, Pharmacologic Substance
(T121)
|
MSH |
D006629
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English |
hirudin, Hirudins [Chemical/Ingredient], HIRUDIN, Hirudins |
Swedish |
Hirudiner
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Czech |
hirudiny
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Finnish |
Hirudiinit
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Russian |
GIRUDIN, GIRUDINY, ГИРУДИН, ГИРУДИНЫ |
Polish |
Hirudyny
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French |
Hirudines
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German |
Hirudine
|
Italian |
Irudine
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Portuguese |
Hirudinas
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Spanish |
Hirudinas
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