Exert cytotoxic effects via transfer of alkyl group
DNA alkylation (key to cellular lethality)
Chemically react with many cellular constituents
DNA cross linking is a primary role of agents
Replicating cells are most susceptible to agents
Alkylating Agents are not cell cycle specific
Bis (chloroethyl) amines
Other drugs causing alkylation
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This page was written by Scott Moses, MD, last revised on 10/21/2007 and last published on 8/7/2019.