II. Pathophysiology

  1. Cell neoplasia residing in lymphoid tissue
  2. Reticuloendothelial organ infiltration

III. Types

  1. Hodgkin's Lymphoma
    1. Localized disease with contiguous nodal spread
    2. Mediastinal involvement
    3. Curability >75%
    4. Systemic Symptoms (Fever, Night Sweats, weight loss)
  2. Non-Hodgkin's Lymphoma
    1. Non-contiguous nodal spread
    2. Extranodal involvement
    3. Abdominal and Bone Marrow involvement
    4. Curability <25%

IV. Risk Factors

  1. Inherited Immunodeficiency Disease
    1. Klinefelter's Syndrome
    2. Chediak-Higashi Syndrome
    3. Ataxia telangiectasia syndrome
    4. Wiskott-Aldrich Syndrome
    5. Common variable Immunodeficiency disease
  2. Acquired Immunodeficiency
    1. Iatrogenic immunosuppression
    2. Acquired Immunodeficiency Syndrome
    3. Acquired hypogammaglobulinemia
  3. Autoimmune Disease
    1. Sjogren's Syndrome
    2. Nontropical Sprue
    3. Rheumatoid Arthritis
    4. Systemic Lupus Erythematosus
  4. Chemical or drug exposure
    1. Phenytoin (Dilantin)
    2. Radiation Therapy
    3. Chemotherapy
  5. Viral Association
    1. Epstein-Barr Virus
    2. Human T-Cell LeukemiaVirus

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Ontology: Lymphoma (C0024299)

Definition (MEDLINEPLUS)

Lymphoma is a cancer of a part of the immune system called the lymphatic system. There are many types of lymphoma. One type is called Hodgkin disease. The rest are called non-Hodgkin lymphoma.

Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors can't determine why a person gets non-Hodgkin lymphoma.

Non-Hodgkin lymphoma can cause many symptoms, such as

  • Swollen, painless lymph nodes in the neck, armpits or groin
  • Unexplained weight loss
  • Fever
  • Soaking night sweats
  • Coughing, trouble breathing or chest pain
  • Weakness and tiredness that don't go away
  • Pain, swelling or a feeling of fullness in the abdomen

Your doctor will perform an exam and lab tests to determine if you have lymphoma.

NIH: National Cancer Institute

Definition (NCI_CDISC) A malignant neoplasm composed of lymphocytes of B- or T/NK-cell phenotype.
Definition (NCI) A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas.
Definition (NCI_NCI-GLOSS) Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One kind is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.
Definition (MSH) A general term for various neoplastic diseases of the lymphoid tissue.
Definition (CSP) malignant (clonal) proliferation of B- or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites; general term for various neoplastic diseases of the lymphoid tissue.
Concepts Neoplastic Process (T191)
MSH D008223
ICD10 M9590/3 , C85.9
SnomedCT 115244002, 118600007, 21964009, 188695001, 188694002, 189965002, 188704004, 189959002, 134218000, 269627002, 188676008
LNC LA15685-3
English Germinoblastic Sarcomas, Germinoblastoma, Germinoblastomas, Lymphoma, Reticulolymphosarcoma, Reticulolymphosarcomas, Sarcoma, Germinoblastic, Sarcomas, Germinoblastic, Lymphoma, Malignant, Lymphomas, Malignant, Malignant Lymphomas, Germinoblastic Sarcoma, LYMPHOMA MALIGNANT, Lymphoma malignant, Malignant lymphoma NOS, Lymphoma morphology, Malig.lymphoma NOS-unspec site, Malignant lymphoma NOS of unspecified site, Lymphoma (Hodgkin and Non-Hodgkin), Lymphoma NOS, [M]Lymphoma NOS, [M]Malignant lymphoma NOS, Malignant lymphoma - category, Malignant lymphoma (category), malignant lymphoma (diagnosis), malignant lymphoma, Malignant lymphoma, no ICD-O subtype, Lymphoma [Disease/Finding], malignant lymphomas, lymphoma malignant, lymphomas, lymphomas malignant, Lymphomatous, Malignant lymphoma NOS (disorder), [M]Reticulolymphosarcoma NOS, [M]Malignant lymphoma NOS (disorder), Malignant lymphoma NOS of unspecified site (disorder), Lymphoma morphology (morphologic abnormality), Lymphosarcoma, Malignant lymphoma, no ICD-O subtype (morphologic abnormality), Malignant lymphoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality), Malignant lymphoma, no International Classification of Diseases for Oncology subtype, Lymphomas, LYMPHOMA, MALIGNANT, LYMPHOMA (HODGKIN AND NON-HODGKIN), LYMPHOMA (HODGKIN'S AND NON-HODGKIN'S), MALIGNANT LYMPHOMA, Lymphoma, NOS, LYMPHOMA, Malignant lymphoma, Lymphoma (clinical), Malignant lymphoma (clinical), Malignant lymphoma (disorder), Malignant lymphoma - category (morphologic abnormality), lymphoma, germinoblastoma, reticulolymphosarcoma, Malignant lymphoma, NOS, Malignant Lymphoma, Lymphoma (Hodgkin's and Non-Hodgkin's)
Portuguese LINFOMA MALIGNO, Linfoma mligno, Linfoma maligno NE, Linfoma maligno, Linfoma NE, Germinoblastoma, Linfoma Maligno, Linfoma, Reticulolinfossarcoma, Sarcoma Germinoblástico
Spanish LINFOMA MALIGNO, morfología: linfoma maligno, no clasificado como subtipo en CIE - O, Linfoma maligno NEOM, Linfoma NEOM, Linfoma maligno, linfoma maligno (categoría, anomalía morfológica), linfoma maligno - categoría, linfoma maligno - categoría (anomalía morfológica), linfoma maligno (categoría, anomalía morfológica) (anomalía morfológica), linfoma hodgkiniano Y/O no hodgkiniano, linfoma de localización no especificada, SAI (trastorno), linfoma, SAI (trastorno), linfoma de localización no especificada, SAI, morfología de un linfoma (anomalía morfológica), linfoma, SAI, Malignant lymphoma NOS, morfología de un linfoma, linfoma (clínico), linfoma maligno (clínico), linfoma maligno (trastorno), linfoma maligno, linfoma, morfología: linfoma maligno, no clasificado como subtipo en CIE - O (anomalía morfológica), reticulolinfosarcoma, Linfoma, Germinoblastoma, Linfoma Maligno, Reticulolinfosarcoma, Sarcoma Germinoblástico
Dutch lymfoom NAO, lymfoom maligne, maligne lymfoom NAO, maligne lymfoom, lymfoom, Germinoblastoom, Lymfoom, Lymfoom, maligne, Reticulolymfosarcoom, Sarcoom, germinoblastair
French Lymphome malin SAI, Lymphome SAI, LYMPHOME MALIGNE, Hématosarcome, Lymphome malin, Lymphome, Lymphomes
German Lymphom NNB, Lymphom boesartig, boesartiges Lymphom, boesartiges Lymphom NNB, LYMPHOM MALIGNE, Germinoblastom, Lymphom, malignes, Lymphom, Retikulolymphosarkom, Sarkom, germinoblastisches
Italian Linfoma maligno NAS, Linfoma NAS, Germinoblastoma, Linfoma maligno, Reticololinfosarcoma, Sarcoma germinoblastico, Linfoma
Japanese 悪性リンパ腫NOS, リンパ腫NOS, リンパシュNOS, リンパシュ, アクセイリンパシュ, アクセイリンパシュNOS, リンパ腫, 悪性リンパ腫, ゲルミノブラストーマ, リンパ腫-悪性, 細網リンパ肉腫, 胚細胞性肉腫, リンホーマ, 肉腫-胚細胞性
Swedish Lymfom
Czech lymfom, lymfom maligní, Maligní lymfom NOS, Maligní lymfom, Lymfom NOS, Lymfom, maligní lymfom
Finnish Lymfooma
Croatian LIMFOM
Polish Immunoblastoma, Chłoniak, Mięsak immunoblastyczny
Hungarian Lymphoma, Lymphoma k.m.n., Malignus lymphoma k.m.n., Rosszindulatú lymphoma, Malignus lymphoma
Norwegian Lymfom, Malignt lymfom