II. Definitions

  1. Transferrin
    1. Iron-binding globulin Protein that is synthesized in the liver and circulates in blood
    2. Primary function is iron transport

III. Pharmacokinetics

  1. Serum Half-Life: 20 days

IV. Interpretation: Normal

  1. 160 to 370 mg/dl (0.16 to 0.37 g/dl)

V. Causes: Increased Transferrin

VI. Causes: Decreased Transferrin

  1. Nephrotic Syndrome
  2. Liver disease
  3. Chronic inflammatory states
  4. Chronic illness
  5. Thalassemia
  6. Neoplasm
  7. Protein Malnutrition

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Ontology: Transferrin (C0040679)

Definition (MSH) An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
Definition (NCI) Serotransferrin (698 aa, ~77 kDa) is encoded by the human TF gene. This protein is involved in iron sequestration and transport.
Definition (CSP) serum beta globin that transports and binds iron.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D014168
SnomedCT 59570008
LNC LP15907-6, LP32171-8, MTHU009837
English Siderophilin, Transferrin, Beta-1 Metal-Binding Globulin, Transferrin [Chemical/Ingredient], transferrin, siderophilin, Metal-Binding Globulin, beta-1, Serotransferrin, Globulin, beta-1 Metal-Binding, beta-1 Metal-Binding Globulin, beta 1 Metal Binding Globulin, Iron binding protein, Transferrin (substance), TF, Granulocyte/Pollen-Binding Protein
Swedish Transferrin
Czech transferin
Finnish Transferriini
Japanese プラズマトランスフェリン, シデロフィリン, トランスフェリン, 鉄結合グロブリン
French Sidérophiline, Transferrine
Italian Siderofillina, Transferrina
Polish Transferyna, Syderofilina
Spanish proteína fijadora de hierro, siderofilina, transferrina (sustancia), transferrina, Transferrina, Siderofilina
German Siderophilin, Transferrin
Portuguese Transferrina, Siderofilina