Definition (NCI_NCI-GLOSS)
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The protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor.
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Definition (NCI)
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Epidermal growth factor receptor (1210 aa, ~134 kDa) is encoded by the human EGFR gene. This protein plays a role in cell-cell adhesion, cell migration, cell proliferation and signal transduction.
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Definition (MSH)
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A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
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Concepts |
Receptor
(T192)
, Amino Acid, Peptide, or Protein
(T116)
, Enzyme
(T126)
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MSH |
D011958
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SnomedCT |
86960007
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LNC |
LP18396-9, MTHU004296 |
English |
EGF Receptor, Urogastrone Receptor, Epidermal Growth Factor Receptor, TGF-alpha Receptor, Epidermal Growth Factor Receptor Kinase, Epidermal Growth Factor Receptor Protein-Tyrosine Kinase, RECEPT EPIDERMAL GROWTH FACTOR, RECEPT TRANSFORMING GROWTH FACTOR ALPHA, RECEPT EGF, TRANSFORMING GROWTH FACTOR ALPHA RECEPT, ERBB PROTO ONCOGENE PROTEIN 001, C ERBB PROTEIN 001, EPIDERMAL GROWTH FACTOR RECEPT, EGF RECEPT, RECEPT TGF ALPHA, UROGASTRONE RECEPT, RECEPT UROGASTRONE, TGF ALPHA RECEPTOR, Epidermal growth factor-urogastrone receptor site, Proto-Oncogene Protein, erbB-1, erbB 1 Proto Oncogene Protein, erbB-1 Proto-Oncogene Protein, Receptor, Transforming-Growth Factor alpha, Transforming Growth Factor alpha Receptor, Receptor, TGF alpha, Receptor, TGF-alpha, Receptor, EGF, Receptor, Epidermal Growth Factor, Receptor, Urogastrone, Receptors, Epidermal Growth Factor-Urogastrone, Receptor, Epidermal Growth Factor [Chemical/Ingredient], Receptors, Epidermal Growth Factor, egf receptors, egfr, epidermal factor growth receptors, epidermal growth factor receptor (EGFR), Receptor, Transforming Growth Factor alpha, Epidermal Growth Factor Receptor Protein Tyrosine Kinase, Receptor Tyrosine-Protein Kinase erbB-1, EC 2.7.10.1, Proto-Oncogene c-erbB-1, c erbB 1 Protein, c-erbB-1 Protein, Epidermal growth factor receptor, ErbB1, HER1, Proto oncogene c ErbB 1 Protein, ErbB-1 Receptor, Receptor, ErbB 1, Resceptor Tyrosine-protein Kinase erbB-1, Receptor, ErbB-1, Protein, Proto-oncogene c-ErbB-1, Proto-oncogene c-ErbB-1 Protein, c-ErbB-1 Protein, Proto-oncogene, Resceptor Tyrosine protein Kinase erbB 1, Epidermal growth factor-urogastrone receptor (substance), Epidermal growth factor-urogastrone receptor, epidermal growth factor receptor, EGFR, c-erbB-1, erbB-1, ERBB Protein |
Swedish |
Receptor, epidermal tillväxtfaktor
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Czech |
receptor epidermálního růstového faktoru, EGFR |
Finnish |
Epidermaalisen kasvutekijän reseptori
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Italian |
Chinasi dei recettori del fattore di sviluppo epidermico, Proteina erbB-1 proto-oncogena, Recettore alfa-TGF, Recettore per il fattore trasformante di crescita alfa, Recettori del fattore urogastrone di sviluppo epidermico, Recettore EGF, Proteina tirosina-chinasi dei recettori del fattore di sviluppo epidermico, Proteina c-erbB-1, Recettore urogastrone, Recettori del fattore di sviluppo epidermico |
Russian |
RETSEPTORY EPIDERMAL'NOGO FAKTORA ROSTA-UROGASTRONA, RETSEPTOR EPIDERMAL'NOGO FAKTORA ROSTA, EGF-URO RETSEPTORY, PROTEIN-TIROZIN-KINAZA RETSEPTORA EPIDERMAL'NOGO FAKTORA ROSTA, EGF-RETSEPTORA KINAZA, EPIDERMAL'NOGO FAKTORA ROSTA-UROGASTRONA RETSEPTORY, UROGASTRONA RETSEPTORY, EPIDERMAL'NOGO FAKTORA ROSTA RETSEPTORA PROTEIN-TIROZIN-KINAZA, EPIDERMAL'NOGO FAKTORA ROSTA RETSEPTORY, EGF-URO РЕЦЕПТОРЫ, EGF-РЕЦЕПТОРА КИНАЗА, ПРОТЕИН-ТИРОЗИН-КИНАЗА РЕЦЕПТОРА ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА, РЕЦЕПТОРЫ ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА-УРОГАСТРОНА, РЕЦЕПТОР ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА, УРОГАСТРОНА РЕЦЕПТОРЫ, ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА РЕЦЕПТОРА ПРОТЕИН-ТИРОЗИН-КИНАЗА, ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА РЕЦЕПТОРЫ, ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА-УРОГАСТРОНА РЕЦЕПТОРЫ |
German |
ERBB PROTO ONKOGENPRODUKTE 001, ERBB PROTO ONKOGEN PROTEIN 001, PROTO ONKOGEN PROTEIN C ERBB 001, C ERBB PROTEIN 001, EGF-Rezeptor-Kinase, EGF-URO-Rezeptoren, Epidermale Wachstumsfaktorrezeptor-Kinase, Epidermale Wachstumsfaktorrezeptor-Protein-Tyrosin-Kinase, Rezeptoren, Epidermiswachstumsfaktor-Urogastron-, Transformierender Wachstums-Faktor-Alpha-Rezeptor, EGF-Rezeptor, Epidermale Wachstumsfaktorrezeptor, Rezeptor, EGF-, Rezeptor, TGF-alpha, Rezeptor, Urogastron-, Rezeptor, epidermaler Wachstumsfakor-, Rezeptor, transformierender Wachstumsfaktor Alpha, TGF-alpha-Rezeptor, Urogastronrezeptor, Proto-Onkogen-Protein, c-erbB-1, c-erbB-1-Protein, erbB-1-Proto-Onkogen-Protein, erbB-1-Proto-Onkogenprodukte |
Croatian |
RECEPTOR, EPIDERMALNI ČIMBENIK RASTA, RECEPTOR, EPIDERMALNI FAKTOR RASTA |
Polish |
Receptor kinazy białkowo-tyrozynowej czynnika wzrostu naskórka, Receptory urogastronu, Receptory czynnika wzrostu naskórka-urogastron, Białko proto-onkogenne erbb-1, Receptor naskórkowego czynnika wzrostu, Receptor EGF, Receptor tgf-alfa, Receptor czynnika wzrostu alfa transformującego, Receptor czynnika wzrostu naskórka |
Japanese |
c-erbB-1癌原遺伝子蛋白質, erbB-1癌原遺伝子蛋白質, EGF-URO受容体, EGF-ウロガストロン受容体, EGF受容体, c-erbB-1蛋白質, ウロガストロン受容体, 上皮成長因子ウロガストロン受容体, 上皮成長因子受容体, 受容体-EGF-ウロガストロン, 受容体-EGF, 形質転換成長因子アルファ受容体, EGFレセプター, TGFα受容体, TGFアルファ受容体, 上皮成長因子受容体蛋白質チロシンキナーゼ, 受容体-TGFα, 受容体-ウロガストロン, 受容体-上皮成長因子, 受容体-上皮成長因子ウロガストロン, 癌原遺伝子蛋白質c-erbB-1, 癌原遺伝子蛋白質erbB-1 |
Portuguese |
Proteína Tirosina Quinase Receptora do Fator de Crescimento Epidérmico, Proteína-Tirosina Quinase Receptora do Fator de Crescimento Epidérmico, Proteína c-erbB-1, Proteína do Proto-Oncogene erbB-1, Receptor do Fator de Crescimento Epidérmico, Receptor do Fator de Crescimento Epidérmico Proteína-Tirosina Quinase, Receptores de Crescimento Epidérmico Fator Urograstrona, Receptor de TGF-alfa, Receptor de Urogastrona, Receptor do EGF, Receptor do Fator Transformador do Crescimento alfa |
Spanish |
receptor de factor de crecimiento epidérmico - urogastrona (sustancia), receptor de factor de crecimiento epidérmico - urogastrona, Proteína c-erbB-1, Proteína de Protooncogén erbB-1, Receptores de Crecimiento Epidérmico Factor Urogastrona, Receptor del Factor de Crecimiento Epidérmico, Proteína-Tirosina Quinasa Receptora de Factor de Crecimiento Epidérmico, Receptor de TGF-alfa, Receptor de Urogastrona, Receptor del EGF, Receptor del Factor Transformador de Crecimiento alfa |
French |
EGF, récepteur, Facteur croissance épidermique, récepteur, Protéine proto-oncogène erbB-1, Récepteur facteur croissance épidermique |