II. Pathophysiology

  1. Initiated by vascular Occlusion

III. Images

  1. Overview
    1. pathClottingCascade.png

IV. Physiology: Pathway

  1. See Anticoagulation (Anticoagulant medications)
  2. Fibrin degradation pathway
    1. tPA (tissue Plasminogen Activator) cleaves Plasminogen
    2. Plasminogen cleaved into Plasmin
    3. Plasmin cleaves Fibrin into Fibrin Degradation Products
  3. Thrombin removal
    1. Fibrin clot absorbs excess Thrombin
    2. Anti-Thrombin III inactivates Thrombin

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