II. Background

  1. Cost: $20/5g tube

III. Indications

  1. Severe Aphthous Ulcers

IV. Mechanism: Reduces local inflammation

  1. Inhibits histamines
  2. Inhibits Leukotrienes

V. Efficacy

  1. Speeds up ulcer healing by 1 day

VI. Dosing

  1. Apply 1/4 inch oral paste to ulcer after meals and qhs
  2. Start as soon as symptom onset
  3. Use until ulcer heals up to 10 days

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Related Studies

Ontology: amlexanox (C0103049)

Definition (NCI) An anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C045742
SnomedCT 108897008, 413507000
English 2-amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3b)pyridine-3-carboxylic acid, 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-, amlexanox, amoxanox, 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic Acid, 2-Amino-7-(1-methylethyl)-5-oxo-, amlexanox (medication), amlexanox [Chemical/Ingredient], 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic Acid, Amlexanox (substance), Amlexanox, Amlexanox (product), AMLEXANOX
Spanish amlexanox (sustancia), amlexanox, amlexanox (producto)

Ontology: Aphthasol (C1097532)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C045742
English Aphthasol, GlaxoSmithKline brand of amlexanox