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Ontology:
Meglitinide
(C0065880)
Definition (NCI)
|
A benzamide belonging to the meglitinide class of antidiabetic agents with hypoglycemic activity. Meglitinide represents the basic structure of the meglitinide-type agents and is not used therapeutically.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C030516
|
SnomedCT |
109075003, 372566000 |
English |
4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzoic acid, meglitinide, meglitinide [Chemical/Ingredient], meglitinides, Meglitinide, MEGLITINIDE, Meglitinide (product), Meglitinide (substance) |
Spanish |
meglitinida (producto), meglitinida (sustancia), meglitinida |
Ontology:
repaglinide
(C0246689)
Definition (NCI)
|
A nonsulfonylurea insulin secretagogue belonging to the melgitinide class with hypoglycemic activity. Repaglinide is rapidly absorbed and has a rapid onset and short duration of action. This agent is metabolized in the liver by CYP2C8 and CYP3A4 and its metabolites are excreted in the bile. Repaglinide has a half-life of one hour.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C072379
|
SnomedCT |
109074004, 386964000 |
LNC |
LP34567-5, MTHU017515 |
English |
repaglinide, (+)-2-Ethoxy-alpha-(((S)-alpha-isobutyl-o-piperidinobenzyl)carbamoyl)-p-toluic Acid, Benzoic Acid, 2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)phenyl)butyl)amino)-2-oxoethyl)-,(S)-, repa-glinide, repaglinide (medication), REPAGLINIDE, repaglinide [Chemical/Ingredient], (S)-2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)-phenyl)butyl)amino)-2-oxoethyl)-benzoic acid, Repaglinide, Repaglinide (product), Repaglinide (substance) |
Japanese |
レパグリニド
|
Spanish |
repaglinida (producto), repaglinida (sustancia), repaglinida |
Ontology:
Prandin
(C0722725)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C072379
|
English |
Prandin, repaglinide (Prandin), prandin, Novo Nordisk brand 2 of repaglinide |
Ontology:
nateglinide
(C0903898)
Definition (NCI)
|
A phenylalanine derivative of the meglitinide class of agents with hypoglycemic activity. Nateglinide, compared to repaglitinide, binds with a higher affinity to the SUR1 subunit and with a faster onset of action and a shorter duration of action. This agent is metabolized by the cytochrome P450 isoenzyme CYP2C9, and, to a lesser extent, by CYP3A4. The parent drug and metabolites are mainly excreted in the urine and its half-life is about 1.5 hours.
|
Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
|
MSH |
C060142
|
SnomedCT |
129496008, 134604002, 387070004 |
LNC |
LP64443-2, MTHU026435 |
English |
IPCCPA, N-((4-isopropylcyclohexyl)carbonyl)phenylalanine, nate-glinide, nateglinide (medication), NATEGLINIDE, nateglinide [Chemical/Ingredient], nateglinide, D-phenylalanine, N-((trans-4-(1-methylethyl)cyclohexyl)carbonyl)-, senaglinide, Nateglinide (product), Nateglinide (substance), Nateglinide |
Spanish |
nateglinida (concepto no activo), nateglinida (producto), nateglinida (sustancia), nateglinida |
Ontology:
Starlix
(C1323198)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C060142
|
English |
starlix, Starlix, Novartis brand of nateglinide |