II. Background

  1. Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
    1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
    2. Although FDA Pregnancy Categories are no longer FDA designated, they are included here
      1. As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking

III. Category: Class A (No risk in controlled human studies)

  1. Dessicated Thyroid (Armour Thyroid)
  2. Levothyroxine (T4 or Synthroid)
  3. Liothyronine (T3 or Cytomel)

IV. Category: Class B (No risk in controlled animal studies)

V. Category: Class C (Small risk in controlled animal studies)

  1. Acetohexamide
  2. Beclomethasone
  3. Betamethasone
  4. Bromocriptine
  5. Chlorpropamide (Diabinase)
  6. Dexamethasone
  7. Glipizide (Glucotrol)
  8. Glyburide (Micronase or DiaBeta)
  9. Triamcinolone

VI. Category: Class D (Strong evidence of risk to the human fetus)

VII. Category: Class X (Very high risk to the human fetus)

  1. Clomiphene (Clomid)
  2. Danazol
  3. Diethylstilbesterol (DES)
  4. Estrogens (all)
  5. Iodide I-131
  6. Leuprolide (Leupron)
  7. Norethindrone
  8. Norethynodrel
  9. Norgestrel
  10. Oral Contraceptives

VIII. References

  1. Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
  2. Larimore (2000) Prim Care 27(1):35-53 [PubMed]

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