II. Mechanism

  1. Non-Selective Beta Blocker
  2. Beta 1 Adrenergic Receptor Antagonist
    1. Decreases Heart Rate, Cardiac Output, and Sympathetic System output (decreased renin release)
  3. Beta 2 Adrenergic Receptor Antagonist
    1. Risk of bronchoconstriction

IV. Indications: Selective Beta Blockers Preferred instead of Propranolol

V. Adverse Effects

  1. See Beta Blocker
  2. Transient Hypertension
    1. Beta 2 Adrenergic Receptor Antagonists transiently constrict large arteries
  3. CNS Adverse Effects
    1. CNS penetration
  4. Rebound Hypertension
    1. Sudden discontinuation of Propranolol

VI. Drug Interactions

  1. Cimetidine
    1. Increases Propanolol serum levels

VII. Dosing: Oral

  1. Regular: 40 mg PO bid (MAX: 640 mg/day)
  2. Extended: 80 mg PO qd (MAX: 320 mg/day)

VIII. Dosing: Intravenous

  1. Load: 1-3 mg IV over 2-5 minutes
  2. Repeat every 2 minutes to a total dose of 0.1 mg/kg
  3. Sustained response for 6-8 hours

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Related Studies

Cost: Medications

propranolol (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
PROPRANOLOL 10 MG TABLET Generic $0.16 each
PROPRANOLOL 20 MG TABLET Generic $0.22 each
PROPRANOLOL 20 MG/5 ML SOLN Generic $0.09 per ml
PROPRANOLOL 40 MG TABLET Generic $0.25 each
PROPRANOLOL 60 MG TABLET Generic $0.63 each
PROPRANOLOL 80 MG TABLET Generic $0.47 each
PROPRANOLOL ER 120 MG CAPSULE Generic $1.58 each
PROPRANOLOL ER 160 MG CAPSULE Generic $2.40 each
PROPRANOLOL ER 60 MG CAPSULE Generic $1.02 each
PROPRANOLOL ER 80 MG CAPSULE Generic $1.32 each
inderal (on 1/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
INDERAL XL 120 MG CAPSULE $22.30 each
INDERAL XL 80 MG CAPSULE $21.97 each

Ontology: Propranolol (C0033497)

Definition (NCI) A synthetic, nonselective beta-adrenergic receptor blocker with antianginal, antiarrhythmic, antihypertensive properties. Propranolol competitively antagonizes beta-adrenergic receptors, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output.
Definition (CSP) noncardioselective beta adrenergic antagonist; used in treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hyperthyroidism, migraine; pheochromocytoma, etc.
Definition (MSH) A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011433
SnomedCT 372772003, 55745002
LNC LP16266-6, MTHU005037
English Propranolol, Propanolol, 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol, Propranolol [Chemical/Ingredient], propanolol, 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, PROPRANOLOL, propranolol, Propranolol (product), Propranolol (substance)
Swedish Propranolol
Czech propranolol
Finnish Propranololi
Japanese 塩酸プロプラノロール, アイデイトロール, インデラル, シンプラール, ソラシロール, メントリース, ノルモテンス, ラピノーゲン, サワタールLA, デキスプロプラノロール, プロパノロール, Tag錠, プロプラノロール
Polish Propranolol, Inderal
Spanish Propanolol, propranolol (producto), propranolol (sustancia), propranolol, Propranolol
Portuguese Propanolol, Propranolol
French Propranolol
German Propranolol
Italian Propanololo

Ontology: Inderal (C0591636)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011433
English inderal, Inderal