II. Indications

  1. Refractory Hypertension
    1. Very effective outpatient agent in oral form patients with Refractory Hypertension
  2. Hypertensive Emergency
    1. Nicardipine has replaced intravenous Labetalol for Hypertensive Emergency
      1. Difficult to achieve Blood Pressure control in Hypertensive Crisis despite titration
      2. Short acting
    2. Labetalol is a preferred agent when compared with Hydaralazine and Clonidine

III. Mechanism

  1. Combination of classes
    1. Alpha Adrenergic Antagonist and
    2. Nonselective Beta Blocker
  2. Primary activity is as a negative inotrope
    1. Chronotropic effect is mild

IV. Dosing

  1. Oral: 100 mg PO bid (Maximum: 2400 mg/day)
  2. Intravenous: 20 mg IV q10 minutes (Maximum: 200 mg)

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Cost: Medications

labetalol (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
LABETALOL HCL 100 MG TABLET Generic $0.22 each
LABETALOL HCL 200 MG TABLET Generic $0.26 each
LABETALOL HCL 300 MG TABLET Generic $0.47 each