II. Indications
-
Refractory Hypertension
- Very effective outpatient agent in oral form patients with Refractory Hypertension
-
Hypertensive Emergency
-
Nicardipine has replaced intravenous Labetalol for Hypertensive Emergency
- Difficult to achieve Blood Pressure control in Hypertensive Crisis despite titration
- Short acting
- Labetalol is a preferred agent when compared with Hydaralazine and Clonidine
-
Nicardipine has replaced intravenous Labetalol for Hypertensive Emergency
III. Mechanism
- Combination of classes
- Alpha Adrenergic Antagonist and
- Nonselective Beta Blocker
- Primary activity is as a negative inotrope
- Chronotropic effect is mild
IV. Dosing
- Oral: 100 mg PO bid (Maximum: 2400 mg/day)
- Intravenous: 20 mg IV q10 minutes (Maximum: 200 mg)
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Related Studies (from Trip Database) Open in New Window
| labetalol (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| LABETALOL HCL 100 MG TABLET | Generic | $0.22 each |
| LABETALOL HCL 200 MG TABLET | Generic | $0.26 each |
| LABETALOL HCL 300 MG TABLET | Generic | $0.47 each |
