II. Dosing
- Start: 50 mg PO qd for 3 days
- Next: 50 mg PO bid for 3 days
- Next: 100 PO qhs for 3 days
- Therapeutic dose: 150 PO qhs
- Maximum: 250 mg PO qhs
III. Pharmacokinetics
- Serum Half Life: 21 hours
- Therapeutic plasma level: 125 to 300
IV. Adverse effects
- See Tricyclic Antidepressants
- Much less adverse effects than tertiary amines
- Moderate adverse effects
V. Precautions
- See Tricyclic Antidepressants
- Serious cardiotoxicity in overdosage
VI. Advantages
- Activating
- Inexpensive
- Attention Deficit Hyperactivity Disorder effect
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desipramine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
DESIPRAMINE 10 MG TABLET | Generic | $0.10 each |
DESIPRAMINE 100 MG TABLET | Generic | $0.56 each |
DESIPRAMINE 25 MG TABLET | Generic | $0.18 each |
DESIPRAMINE 50 MG TABLET | Generic | $0.46 each |