I. Pathophysiology

  1. Nutritional disease results from Thiamine deficiency

II. Causes

  1. Chronic Alcoholism
  2. Thiamine deficiency
  3. Malnutrition
  4. Diuresis
  5. Dialysis
  6. High carbohydrate intake

III. Symptoms

  1. Weakness, irritability
  2. Nausea, Vomiting
  3. Burning feet
  4. Pruritus

IV. Signs

  1. Neurologic
    1. Tremor
    2. Diminished reflexes in lower limbs
    3. Muscle atrophy
  2. Cardiac: Congestive Heart Failure (Wet Beriberi)
    1. Pedal Edema
    2. Pleural Effusions

V. Lab

  1. Complete Blood Count
    1. Anemia
  2. Blood Thiamine lowered
  3. Erythrocyte transketolase decreased
  4. Blood pyruvate high

VI. Diagnosis

  1. Test dose of Thiamine results in no urinary excretion

VII. Radiology: Chest XRay

  1. Cardiomegaly

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Ontology: Beriberi (C0005122)

Definition (MSH) A disease caused by a deficiency of thiamine (vitamin B1) and characterized by polyneuritis, cardiac pathology, and edema. The epidemic form is found primarily in areas in which white (polished) rice is the staple food, as in Japan, China, the Philippines, India, and other countries of southeast Asia. (Dorland, 27th ed)
Concepts Disease or Syndrome (T047)
MSH D001602
ICD9 265.0
ICD10 E51.1 , E51.11
SnomedCT 190625009, 36656008, 154725000, 267491008, 35843007
English Beriberi, BERIBERI, POLYNEURITIS, ENDEMIC, Beriberi, NOS, Beri-beri, beriberi (diagnosis), beriberi, Beri beri, Beriberi NOS, Beriberi [Disease/Finding], beri-beri, endemic polyneuritis, beribery, bery bery, beri beri, Beriberi (disorder), Kakke, Kakkè, deficiency; vitamin, B1, beriberi, deficiency; vitamin, thiamine, beriberi, vitamin; deficiency, B1, beriberi, vitamin; deficiency, thiamine, beriberi, Beri Beri
Dutch beriberi, deficiëntie; vitamine, B1, beriberi, deficiëntie; vitamine, thiamine, beriberi, vitamine; deficiëntie, B1, beriberi, vitamine; deficiëntie, thiamine, beriberi, Beriberi, Beriberi (droog), Beriberi (nat), Vitamine-B1-tekort
Italian Beri Beri, Beriberi
Portuguese Beribéri, Beriberi
Spanish Beri beri, Beriberi, Beri-beri, beriberi (trastorno), beriberi, hipovitaminosis B1
Japanese 脚気, カッケ
Swedish Beriberi
Czech beri-beri, Beri beri
Finnish Beriberi
Russian BERI-BERI, POLINEVRIT ALIMENTARNYI, БЕРИ-БЕРИ, ПОЛИНЕВРИТ АЛИМЕНТАРНЫЙ
Korean 각기
Polish Awitaminoza B1, Beri-beri
Hungarian Beriberi
French Béribéri
German Beriberi, Thiamin-Mangelkrankheit

Ontology: Thiamine Deficiency (C0039841)

Definition (MSH) A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
Definition (CSP) nutritional condition produced by a deficiency of thiamine in the diet, characterized by anorexia, irritability, and weight loss; later, patients experience weakness, peripheral neuropathy, headache, and tachycardia; in addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption.
Concepts Disease or Syndrome (T047)
MSH D013832
ICD10 E51.9 , E51
SnomedCT 190628006, 191088004, 399357009, 35843007, 190624008, 154725000, 267491008
English Thiamine deficiency disease, Deficiencies, Thiamine, Deficiency, Thiamine, Thiamine Deficiencies, Thiamine Deficiency, THIAMINE DEFICIENCY, Thiamin deficiency, NOS, VITAMIN B1 DEFICIENCY, Vitamin B1 deficiency, NOS, Thiamine defic, unspecif, Thiamine deficiency, unspecified, [X]Thiamine defic, unspecif, [X]Thiamine deficiency, unspecified, THIAMINE DEFIC, DEFIC THIAMINE, vitamin B1 deficiency, vitamin B1 deficiency (diagnosis), [X]Thiamine deficiency, unspecified (disorder), Thiamine Deficiency [Disease/Finding], deficiency vitamin b1, thiamin deficiency, deficiency thiamin, deficiencies thiamin, deficiency thiamine, vitamin b1 deficiency, Aneurin deficiency, Thiamin deficiency, Vitamin B1 deficiency, Thiamine deficiency, Thiamin deficiency (disorder), thiamine deficiency, deficiency; aneurin, deficiency; thiamine, deficiency; vitamin, B1, deficiency; vitamin, thiamine, aneurin; deficiency, thiamine; deficiency, vitamin; deficiency, B1, vitamin; deficiency, thiamine
Italian Carenza di vitamina B1, Carenza di tiamina
Portuguese Deficiência de Vitamina B1, Deficiência de Vitamina B 1, Carência de vitamina B1, Deficiência de Tiamina
Japanese ビタミンB1欠乏, ビタミンB1ケツボウ, サイアミン欠乏症, チアミン欠乏症, ビタミンB1欠乏症, チアミン欠乏, ビタミンB1欠乏
Swedish Tiaminbrist
Czech thiamin - nedostatek, Deficit vitaminu B1
Spanish Thiamine deficiency, Vitamin B1 deficiency, [X]Thiamine deficiency, unspecified, [X]deficiencia de tiamina, no especificada (trastorno), [X]deficiencia de tiamina, no especificada, deficiencia de tiamina (trastorno), deficiencia de tiamina, deficiencia de vitamina B1, Déficit de vitamina B1, Deficiencia de Tiamina, Deficiencia de Vitamina B 1, Deficiencia de Vitamina B1
Finnish Tiamiinipuutos
Russian TIAMINA NEDOSTATOCHNOST', ТИАМИНА НЕДОСТАТОЧНОСТЬ
German Thiaminmangel [Vitamin-B1-Mangel], Thiaminmangel, nicht naeher bezeichnet, VITAMIN B A 01 MANGEL, Vitamin B1-Mangel, Thiaminmangel, Vitamin-B1-Mangel
Korean 상세불명의 티아민 결핍증, 티아민 결핍증
Polish Niedobór tiaminy, Hipowitaminoza B1
Hungarian B1 vitaminhiány
Dutch aneurine; deficiëntie, deficiëntie; aneurine, deficiëntie; thiamine, deficiëntie; vitamine, B1, deficiëntie; vitamine, thiamine, thiamine; deficiëntie, vitamine; deficiëntie, B1, vitamine; deficiëntie, thiamine, Thiaminedeficiëntie, niet gespecificeerd, vitamine-B1-deficiëntie, Thiaminegebrek, Vitamine-B1-gebrek, Deficiëntie, thiamine-, Thiaminedeficiëntie
French Carence en vitamine B1, Carence en thiamine, Carence en vit B1, Déficit en thiamine