II. Dosing

  1. Irritable Bowel Syndrome with Constipation: 8 mcg orally twice daily
  2. Chronic Constipation: 24 mcg orally twice daily

III. Adverse Effects

  1. Nausea (with 24 mcg dose)
  2. Diarrhea (with 24 mcg dose)
  3. Chest Pain or Dyspnea
    1. Follows dose within 1 hour
    2. Resolves within 3 hours

IV. Disadvantages

  1. Low efficacy in Irritable Bowel Syndrome with Constipation: Only 14% respond
  2. Expensive: $200 per month

V. Mechanism

  1. ClC(2) chloride channel opener

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Related Studies

Cost: Medications

amitiza (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
AMITIZA 24 MCG CAPSULES Generic $4.32 each
AMITIZA 8 MCG CAPSULE Generic $4.13 each
lubiprostone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
LUBIPROSTONE 24 MCG CAPSULE Generic $4.32 each
LUBIPROSTONE 8 MCG CAPSULE Generic $4.13 each