II. Dosing
- Irritable Bowel Syndrome with Constipation: 8 mcg orally twice daily
- Chronic Constipation: 24 mcg orally twice daily
III. Adverse Effects
- Nausea (with 24 mcg dose)
- Diarrhea (with 24 mcg dose)
-
Chest Pain or Dyspnea
- Follows dose within 1 hour
- Resolves within 3 hours
IV. Disadvantages
- Low efficacy in Irritable Bowel Syndrome with Constipation: Only 14% respond
- Expensive: $200 per month
V. Mechanism
- ClC(2) chloride channel opener
Images: Related links to external sites (from Bing)
Related Studies
amitiza (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
AMITIZA 24 MCG CAPSULES | Generic | $4.32 each |
AMITIZA 8 MCG CAPSULE | Generic | $4.13 each |
lubiprostone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
LUBIPROSTONE 24 MCG CAPSULE | Generic | $4.32 each |
LUBIPROSTONE 8 MCG CAPSULE | Generic | $4.13 each |