Mental Health Book

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ZolpidemAka: Zolpidem CR, Ambien

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  1. Indication
    1. Insomnia
    2. Sleep maintenance (CR version)
  2. Dose: Regular formulation
    1. Adult: 10 mg orally at bedtime
    2. Elderly: 2.5 to 5 mg orally at bedtime
  3. Dose: Controlled release (CR)
    1. Adult: 12.5 mg orally at bedtime
  4. Pharmacokinetics
    1. Peak onset: <30 minutes
    2. Duration: 4-8 hours (6-8 hours with CR version)
    3. Half-Life: 2-3 hours (longer with CR version)
    4. Metabolized by CYP450 3A4
  5. Mechanism
    1. Nonbenzodiazepine hypnotic agent
    2. Acts at omega 1 subtype Benzodiazepine receptor
    3. No anticonvulsant or myorelaxant effects
  6. Lactation
    1. Compatible with Breast Feeding per AAP
    2. Lack of longterm data - other medications are preferred
  7. Pregnancy
    1. Pregnancy Class B (not CR version)
    2. Lack of longterm data - other medications are preferred
  8. Drug Interactions
    1. Avoid taking with food or immediately after a meal
      1. Delays onset of action
      2. Decreases maximal concentration
    2. Avoid taking with Alcohol
      1. May increase CNS depression
  9. Adverse effects
    1. See Nonbenzodiazepine hypnotic agent for common effects
    2. Abdominal Pain or gastrointestinal upset
    3. Rebound Insomnia
    4. Nightmares
    5. Sleep-eating is more common

zolpidem (C0078839)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC049109
Englishzolpidem, ZOLPIDEM PREPARATION, ZPD
Spanishzolpidem
Parent ConceptsHypnotics and Sedatives (C0020592), Pyridines (C0034255), [CN309] SEDATIVES/HYPNOTICS, OTHER (C0993165), Sedatives (C0036557), Drug allergen (C1320237)
SourcesLNC, MSH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Ambien (C0487782)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC049109
EnglishAmbien, Sanofi brand of zolpidem tartrate
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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