Pharmacology Book

http://www.fpnotebook.com/

Natural Progesterone

Aka: Natural Progesterone, Dioscorea, Yam extract, Wild Yam
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  1. Mechanism
    1. Yams are among 600 species of Dioscorea family
    2. Yams have Estrogenic Activity in animals
    3. Diosgenin is derived from yams
      1. Natural Progesterone source
      2. Highest concentration of Disogenin in Mexican Yam
      3. Diosgenin not converted to Progesterone in humans
      4. Diosgenin converted in labs to Progesterone
  2. Current Uses
    1. Premenstrual Syndrome
    2. Menopausal symptoms
    3. Osteoporosis
  3. Dosing: Natural Progesterone cream (not Yam extract)
    1. Preparation: 400 mg per ounce
    2. Apply 1/4 to 1/2 teaspoon to vagina per day
  4. Efficacy
    1. Yams
      1. Yam extract has no Progesterone activity in humans
      2. Yam Estrogen levels are not high enough for benefit
    2. Natural Progesterone derived from Diosgenin
      1. May relieve some post-menopausal symptoms
      2. Minimal or no benefit in Osteoporosis
  5. Adverse Effects
    1. Yams are an Unopposed Estrogen source
      1. Risk of Endometrial Cancer
      2. May require Endometrial Biopsy

Wild yam extract (C0772357)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
English Wild Yam Extract, WILD YAM, Wild Yam, wild yam (medication), wild yams, Wild yam extract, wild yam
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Genus Dioscorea (C0936043)

Definition (MSH) A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.
Concepts Plant (T002)
MSH D027742
SnomedCT 50918006
English Dioscorea, NOS, Dioscorea L., Dioscoreas, dioscorea, yam, yam plant, yams, Yam, Dioscorea (organism), Genus Dioscorea, Nanarepenta, Tamus, Borderea, Dioscorea
Swedish Dioscorea
Czech Dioscorea
Finnish Dioscorea
Russian IAM, IAMS, DIOSKOREIA, ЯМС, ЯМ, ДИОСКОРЕЯ
French Dioscorée, Dioscorea
Portuguese Inhame, Dioscorea, Dioscorea batata, Inhame-da-China, Inhame-Comum, Dioscorea batatas, Cará-Inhame, Cará-do-Pará, Cará-Doce, Cará-do-Ar, Cará-de-Sapateiro, Cará-de-São-Tomé, Cará-de-Pele-Branca, Cará-de-Pedra, Cará-de-Folha-Miúda, Cará-de-Folha-Colorida, Cará-de-Árvore, Cará-de-Angola, Cará-da-Guiné, Caratinga
Spanish Dioscorea (organismo), Dioscorea
German Dioscorea
Italian Dioscorea
Dutch Dioscorea
Polish Jams, Ignam, Pochrzyn
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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