II. Indications
- Parkinsonism
-
Restless Leg Syndrome
- Moderate to severe symptoms refractory to Pramipexole or Ropinirole
III. Mechanism
- Non-ergot Dopamine Agonist available as a transdermal patch
IV. Technique: Patch Application
- Apply once daily (available in 1, 2, 3, 4, 6 and 8 mg)
- Patch applied daily to a new dry, clean and intact skin site
- Hold patch in place for 20-30 seconds before removing hand
- Appropriate sites include Abdomen, thigh, flank, Shoulder, upper arm
- Wash skin after removal
- Do not repeat the same site for 14 days
- Remove patch prior to MRI, cardioversion
V. Dosing: Parkinsonism
- Start at 2 mg/24 hours
- May start a 4 mg/24h patch in advanced Parkinsonism
- May increase weekly by 2 mg/24h patch to a maximum of 6 mg/24h (8 mg/24h in advanced Parkinsonism)
- Taper patch by 2 mg/24h every 2 days when stopping
VI. Dosing: Refractory Restless Leg Syndrome
- Start at 1 mg/24 hours
- May increase weekly by 1 mg/24h patch to a maximum of 3 mg/24 hours
VII. Adverse Effects
- Pregnancy Category: C
- Lactation: Unknown Safety
VIII. Resources
IX. References
- (2021) Med Lett Drugs Ther 63(1618): 25-32
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 46-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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| NEUPRO 1 MG/24 HR PATCH | $24.38 each | |
| NEUPRO 2 MG/24 HR PATCH | $24.24 each | |
| NEUPRO 3 MG/24 HR PATCH | $24.35 each | |
| NEUPRO 4 MG/24 HR PATCH | $24.35 each | |
| NEUPRO 6 MG/24 HR PATCH | $24.37 each | |
| NEUPRO 8 MG/24 HR PATCH | $24.30 each | |