Pulmonology Book

http://www.fpnotebook.com/

Rifapentine

Aka: Rifapentine, Priftin
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  1. Class
    1. Rifamycin
      1. Inhibits bacterial RNA polymerase
  2. Mechanism
    1. Long-acting Rifampin derivative
  3. Dosing
    1. Tuberculosis
      1. Part of multi-drug regimen; high risk of drug resistance Tb if used alone
      2. Rifapentine 600 mg orally twice weekly for 2 months then once weekly for 4 months
    2. Latent Tuberculosis
      1. Combination of both Isoniazid (INH) and Rifapentine both weekly for 12 weeks
        1. Each dose must be physician observed (due to risk of drug resistant Tuberculosis if stopped early)
      2. Protocol
        1. Rifapentine (Priftin) 900 mg weekly for 12 weeks AND
        2. Isoniazid (INH) 900 mg weekly for 12 weeks
      3. Sterling (2011) N Engl J Med 365:2155-2166
  4. Adverse Reactions
    1. Hyperuricemia
    2. Body secretion discoloration (orange to brown)
      1. Discolors urine and contact lenses
    3. Hepatotoxicity
    4. Thrombocytopenia
  5. Drug Interactions
    1. See Rifampin

rifapentine (C0073372)

Concepts Organic Chemical (T109) , Antibiotic (T195)
MSH C018421
SnomedCT 108686006, 410831004
English 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV, rifapentine, rifapentine (medication), rifapentine [Chemical/Ingredient], Rifapentine (substance), Rifapentine, Rifapentine (product), RIFAPENTINE
Spanish rifapentina (sustancia), rifapentina, rifapentina (producto)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Priftin (C0876758)

Concepts Organic Chemical (T109) , Antibiotic (T195)
MSH C018421
English Priftin, Aventis Behring brand of rifapentine
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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