II. Indications
- Colorectal Cancer (metastatic)
- Gastric or gastroesophageal junction adenocarcinoma (metastatic, refractory)
III. Mechanism
- Trifluridine
- Fluorinated thymidine analog with both antineoplastic and antiviral activity
- As a thymidine analog, Trifluridine is incorporated into DNA
- Inhibits thymidylate synthase
- Inhibits DNA synthesis and Protein synthesis
- Tipiracil
- Thymidine phosphorylase inhibitor
- Thymidine is added to Trifluridine, to slow its metabolism, and potentiate its activity
IV. Medications
- Trifluridine/Tipiracil Tablets: 15 mg/6.14 mg and 20 mg/8.19 mg
V. Dosing
- See other references for disease specific dosing protocols
VI. Pharmacokinetics
- Trifluridine is metabolized by Thymidine phosphorylase
VII. Adverse Effects
- Myelosuppression (severe)
VIII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
- Complete Blood Count (CBC)
- Obtain prior to dosing and again on Day 15 of Chemotherapy cycle
- Complete Blood Count (CBC)
IX. Resources
- Trifluridine-Tipiracil Tablets (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
| trifluridine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TRIFLURIDINE 1% EYE DROPS | Generic | $19.43 per ml |