II. Indications
-
Intermittent Claudication
- Adjunct while taking other antiplatelet medication (e.g. Aspirin, Clopidogrel)
III. Contraindications
- Congestive Heart Failure (increased mortality)
- Caution in severe hepatic insufficiency
- Caution in GFR <25 ml/min
IV. Mechanism
V. Dosing
- Take 100 mg orally twice daily on an empty Stomach
- Indications for half dose (50 mg orally twice daily)
- Use of strong CYP3A4 Inhibitors (e.g. Itraconazole, Erythromycin)
- Use of strong CYP2C19 Inhibitors (e.g. Omeprazole)
VI. Adverse Effects
- Headache
- Palpitations
- Left ventricular outflow obstruction
- Increased risk in patients with sigmoid shaped interventricular septum
VII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
VIII. Drug Interactions
- CYP3A4 Inhibitors (e.g. Itraconazole, Erythromycin)
- CYP2C19 Inhibitors (e.g. Omeprazole)
-
Grapefruit juice
- Increases Cilostazol levels
IX. Efficacy
- Full effect may be delayed for 12 weeks
X. Resources
XI. References
- Balinski (2023) Cilostazol, StatPearls, Treasure Island
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| cilostazol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CILOSTAZOL 100 MG TABLET | Generic | $0.13 each |
| CILOSTAZOL 50 MG TABLET | Generic | $0.11 each |