Human Immunodeficiency Virus Book

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Saquinavir

Aka: Saquinavir, Invirase
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  1. See Also
    1. Anti-Retroviral Therapy
    2. Protease Inhibitor
  2. Mechanism
    1. Protease Inhibitor
  3. Disadvantages
    1. Weak effect
    2. Expensive
    3. May worsen resistance for better drugs
  4. Adverse Effects
    1. Rash
    2. Prolonged QT Interval
    3. Hyperprolactinemia (rare)
  5. Drug Interactions
    1. Garlic supplements (do not use with Saquinavir)
      1. Reduces Saquinavir concentrations by 50%
      2. Levels may remain reduced even after stopiing Garlic
      3. Piscitelli (2002) Clin Infect Dis 34:234-8
  6. Dosing
    1. Saquinavir 600 mg PO tid ($572/month)
    2. If taken without food, may have no antiviral activity
      1. Take within 2 hours after a full meal
      2. Meals increase absorption and decrease GI upset
  7. References
    1. (1998) Med Lett Drugs Ther 40(1041):115
    2. (2009) Treat Guidel Med Lett 7(78): 11-22
    3. Reust (2011) Am Fam Physician 83(12): 1443-51

Saquinavir (C0286738)

Definition (MSH) An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases.
Definition (NCI) A synthetic antiviral agent. Saquinavir, a peptide-like substrate, selectively binds to and inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions. (NCI04)
Definition (CSP) HIV protease inhibitor which acts as an analog of an HIV protease cleavage site.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D019258
SnomedCT 108700005, 372530001
English saquinavir, Saquinavir, Saquinivir, saquinavir (medication), Saquinavir [Chemical/Ingredient], saquinivir, SQV, Saquinavir product, Saquinavir (product), Saquinavir (substance), SAQUINAVIR
Czech saquinavir
Finnish Sakinaviiri
Russian SAKHINAVIR, САХИНАВИР
Japanese サキナビル
Swedish Sakvinavir
Italian Saquinivir, Saquinavir
Polish Sakwinawir
Spanish saquinavir (producto), saquinavir (sustancia), saquinavir, Saquinavir
French Saquinavir
German Saquinavir
Portuguese Saquinavir
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Invirase (C0701215)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D019258
English invirase, Invirase
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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