Endocrinology Book

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Hemoglobin A1C

Aka: Hemoglobin A1C, Glycosylated Hemoglobin, HBA1C, HgbA1c
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  1. Epidemiology
    1. Hemoglobin A1C may be important measure in non-diabetic
    2. Hemoglobin A1C associated mortality (contrast with <5)
      1. Relative risk of Hemoglobin A1C 5.0 to 5.4
        1. All cause mortality: 1.41
        2. Cardiovascular mortality: 2.53
      2. Relative risk of Hemoglobin A1C 5.4 to 6.9
        1. All cause mortality: 2.07
        2. Cardiovascular mortality: 2.46
      3. Relative risk of Hemoglobin A1C 7.0 or higher
        1. All cause mortality: 2.64
        2. Cardiovascular mortality: 5.04
      4. References
        1. Khaw (2001) BMJ 322:15-8
  2. Background
    1. Glycosylated Hemoglobin is not equivalent to A1C
      1. Hemoglobin A1C is 70% total Glycosylated Hemoglobin
  3. Approximating Serum Glucose
    1. Hemoglobin A1C of 6% represents mean Glucose of 130
    2. Each 1% increase in A1C, Glucose increases 30
  4. Interpretation: Correlation to Mean Serum Glucose
    1. Hemoglobin A1C: 5.5% represents mean Glucose of 100
    2. Hemoglobin A1C: 7.0% represents mean Glucose of 150
    3. Hemoglobin A1C: 8.0% represents mean Glucose of 180
    4. Hemoglobin A1C: 9.0% represents mean Glucose of 220
    5. Hemoglobin A1C: 10.0% represents mean Glucose of 250
    6. Hemoglobin A1C: 11.5% represents mean Glucose of 300
    7. Hemoglobin A1C: 13.0% represents mean Glucose of 350
  5. Interpretation: Fasting vs post-prandial Hyperglycemia
    1. Hemoglobin A1C <7.3%:
      1. Postprandial Glucose: 30%
      2. Fasting Glucose: 70%
    2. Hemoglobin A1C 7.3-8.4%
      1. Postprandial Glucose: 50%
      2. Fasting Glucose: 50%
    3. Hemoglobin A1C 8.5-9.2%
      1. Postprandial Glucose: 55%
      2. Fasting Glucose: 45%
    4. Hemoglobin A1C 9.3-10.2%
      1. Postprandial Glucose: 60%
      2. Fasting Glucose: 40%
    5. Hemoglobin A1C >10.2%
      1. Postprandial Glucose: 70%
      2. Fasting Glucose: 30%
    6. References
      1. Monnler (2003) Diabetes Care 26:881-5
  6. Interpretation: Diagnosis of Diabetes Mellitus
    1. Hemoglobin A1C <5.2%: No Diabetes Mellitus
      1. Test Sensitivity: 100%
    2. Hemoglobin A1C >6%: Diabetes Mellitus
      1. Test Specificity: 100%

Hemoglobin, Glycosylated (C0017853)

Concepts Amino Acid, Peptide, or Protein (T116) , Biologically Active Substance (T123)
MSH D006442
SnomedCT 259689004, 143080000, 165678002
English Glycated Hemoglobins, Glycosylated Hemoglobin, Hemoglobin, Glycosylated, Hemoglobins, Glycated, Hemoglobin.glycated, glycosylated hemoglobin, glycosylate hemoglobin, glycosylate haemoglobin, glycosylated hemoglobins, glycated haemoglobin, glycosylated hb, glycated hemoglobin, glycosylated haemoglobin, hemoglobin glycated, Glycated haemoglobin, Glycated hemoglobin, Glycosylated Hb, Glycosylated haemoglobin, Glycosylated hemoglobin, Glycosylated hemoglobin (substance)
Spanish Glycated hemoglobin, Glycated haemoglobin, Glycosylated Hb, glucohemoglobina (sustancia), glucohemoglobina
French Hémoglobine glyquée, Hémoglobine glycosylée, Glycohémoglobine
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Glycosylated hemoglobin A (C0019018)

Definition (MSH) Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
Concepts Amino Acid, Peptide, or Protein (T116) , Biologically Active Substance (T123)
MSH D006442
SnomedCT 103232008, 33601001, 259689004
English Glycohemoglobin A, Glycosylated Hemoglobin A, Hb A1, Hb A1a+b, Hb A1c, HbA1, Hemoglobin A(1), Hemoglobin A, Glycosylated, Glycosylated hemoglobin A, HBA GLYCOSYLATED, HBA 01, HEMOGLOBIN AA 01, HB AC 01, HbA<sub>1c</sub> (substance), Haemoglobin A1c, HbA>1c< (substance), HbA1c, HbA1c (substance), HbA>1c<, Hemoglobin A1c, HbA<sub>1c</sub>, Hemoglobin A, Glycosylated [Chemical/Ingredient], hemoglobin a1c, hba1, hemoglobin a 1, glycosylated hemoglobin a, hb a1, hba1c, haemoglobin a1c, HbA1 - Glycated haemoglobin, HbA1 - Glycated hemoglobin, Glycosylated haemoglobin A, Glycosylated hemoglobin A (substance)
Swedish Hemoglobin A, glykosylerat
Spanish HbA>1c< (sustancia), hemoglobina glucosilada (sustancia), hemoglobina glicosilada A, hemoglobina glucosilada, HbA>1c<, HbA1c, hemoglobina A1c, HbA<sub>1c</sub>, HbA1c (sustancia), HbA<sub>1c</sub> (sustancia), hemoglobina A glucosilada (sustancia), hemoglobina A glucosilada, Glucohemoglobina A, Hb A1c, HbA1, Hemoglobina A(1), Hemoglobina A Glicosilada, Hemoglobina A Glucosilada
Czech HbA1, hemoglobin A glykosylovaný
Finnish Hemoglobiini A1c
French Hb A1, HbA1, Hémoglobine A(1), Hémoglobine A1c, Hb A1c, Hb A1a+b, Hémoglobine A glycosylée, Glycohémoglobine A, Hémoglobine glycosylée A1c, Hémoglobine A1
Italian Hb A1a+b, Emoglobina A(1), Hb A1c, HbA1, Glicoemoglobina A, Hb A1, Emoglobina A glicosilata
Russian GLIKOGEMOGLOBIN A, GEMOGLOBIN A GLIKOZILIROVANNYI, GLIKOZILIROVANNYI GEMOGLOBIN A, GEMOGLOBIN A(1), HB A1C, HBA1, ГЕМОГЛОБИН A(1), ГЕМОГЛОБИН A ГЛИКОЗИЛИРОВАННЫЙ, ГЛИКОГЕМОГЛОБИН A, ГЛИКОЗИЛИРОВАННЫЙ ГЕМОГЛОБИН A
German HBA 01, HB AC 01, HÄMOGLOBIN A 01, Hb A1c, HbA1, Glycohämoglobin A, Glycosyliertes Hämoglobin A, Hämoglobin A(1), Hämoglobin A, glycosyliertes
Polish Hemoglobina A glikozylowana, Glikohemoglobina A
Japanese HbA糖化, グリコシルヘモグロビンA, グリコシル化ヘモグロビンA, グリコヘモグロビンA, ヘモグロビンA1, 糖化血色素A, 血色素A-糖化, グリコヘモグロビン, ヘモグロビンA1c, 糖化HbA, 糖化ヘモグロビンA
Portuguese Glicohemoglobina A, Hb A1c, HbA1, Hemoglobina A(1), Hemoglobina A Glicosilada
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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