II. Definition

  1. Definitive, second trimester Antenatal Screening for fetal chromosomal abnormalities

III. Indications

  1. Antenatal Screening for fetal chromosomal abnormalities for high risk pregnancies

IV. Protocol

  1. Timing
    1. Safest time period: 16-18 weeks gestation
    2. Range of sampling time: 14-20 weeks gestation
  2. Technique
    1. Amniotic fluid sampled transabdominally under Ultrasound guidance

V. Adverse Effects

  1. Pregnancy loss (0.3 to 1% risk)
  2. Vaginal spotting
  3. Amniotic fluid leak
  4. Chorioamnionitis
  5. Fetal injury from Amniocentesis needle
  6. Failed procedure in which fetal cells in amniotic fluid do not grow in culture

VI. Efficacy: Down Syndrome detection

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