II. Indications
- Included in Triple Screen
III. Physiology
- Normally produced at low levels by ovaries
- Elevated in pregnancy
- Produced by placenta
- Precursors supplied by fetus
- Fetal Adrenal Glands
- Fetal liver
IV. Increased Unconjugated Estriol
- Increases throughout normal pregnancy
V. Decreased Unconjugated Estriol
- Trisomy 21 (Down Syndrome)
- Trisomy 18 (Edwards Syndrome)