Second Generation Anti-anaerobe Cephalosporins

Aka: Second Generation Anti-anaerobe Cephalosporins, Cefoxitin, Cefotetan, Cefamandole

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II. Coverage

  1. Bacteroides

III. Indications

  1. Abdominal Surgery prophylaxis
  2. Colorectal surgery prophylaxis

IV. Coverage

  1. Cefoxitin (Mefoxin) 1-2 grams IM or IV every 6-8 hours
  2. Cefotetan (Cefotan) 1-2 grams IM or IV every 12 hours
  3. Cefamandole

V. Downsides

  1. Poor overall activity
  2. Expensive

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