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Modafinil

Aka: Modafinil, Provigil
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  1. Indications
    1. Narcolepsy
    2. Non-FDA approved use
      1. Attention Deficit Hyperactivity Disorder
      2. Fatigue in Multiple Sclerosis
      3. Excessive Sleepiness in myotonic dystrophy
  2. Contraindications (relative)
    1. Coronary Artery Disease
    2. Hypertension
    3. Other cardiovascular disease
  3. Mechanism
    1. Stimulant
  4. Dosing: Adults
    1. ADHD: 100-300 mg PO qd (Not FDA approved)
    2. Narcolepsy: 200 mg qAM
  5. Dosing: Children Age >5 years
    1. ADHD: 50-100 mg PO qd (Not FDA approved)
  6. Efficacy: Narcolepsy
    1. May be slightly less effective then agents above
    2. Less addictive potential then agents above
    3. (1999) Med Lett Drugs Ther 41(1049):30-2
  7. Efficacy: ADHD
    1. Only small studies to show effectiveness and safety
    2. References
      1. Rugino (2001) J Am Acad Child Adolesc Psychiatry 40
      2. Taylor (2000) J Child Adolesc Psychopharmacol 10:311
  8. Adverse Effects
    1. Headache
    2. Nervousness
    3. Dizziness
    4. Depressed mood
    5. Anxiety
    6. Cataplexy
    7. Insomnia
    8. Diarrhea
    9. Nausea
    10. Xerostomia
    11. Anorexia
    12. Paresthesias
    13. Pharyngitis or Rhinitis
  9. References
    1. (2003) Lexi-Comp Drug Database for Pocket PC (7/9/03)
Medication Costs
Provigil (on 2/9/2012 at DrugStore.com)
Provigil 100mg Tablets #30 for $608.38 ($20.28/unit)
Provigil 200mg Tablets #30 for $787.99 ($26.27/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

modafinil (C0066677)

Definition (NCI) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. (NCI04)
Definition (NCI) A drug that is being studied as a treatment for fatigue in patients with cancer. It belongs to the family of drugs called stimulants.
Definition (PDQ) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26661" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C048833
SnomedCT 116082007, 387004007
English benzhydrylsulfinylacetamide, modafinil, modafinil (medication), MODAFINIL, modafinil [Chemical/Ingredient], Modafinil, Modafinil (product), Modafinil (substance)
Spanish modafinilo, modafinilo (producto), modafinil, modafinilo (sustancia), modafinil (producto), modafinil (sustancia)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Provigil (C0722882)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C048833
English Provigil, modafinil (Provigil), provigil, Cephalon brand of modafinil
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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