Obstetrics Book

http://www.fpnotebook.com/

Tocolytic

Aka: Tocolytic, Tocolysis
Advertisement
  1. See Also
    1. Preterm Labor Management
  2. Indications
    1. Preterm Labor
  3. Contraindications (See specific medications)
    1. Fetal Bradycardia <100
    2. Fetal Tachycardia >180
    3. Maternal Systolic Blood Pressure <90 mmHg
    4. Shortness of Breath
    5. Chest Pain
  4. Medications
    1. General Indications
      1. Stops labor for 24-48 hours
      2. Allows maternal transport or steroid doses above
    2. Magnesium Sulfate
      1. Dosing: Start with 4-6 g bolus IV over 20 min, then 1-2 g/h (maximum 3 g/h)
      2. Does not prevent preterm birth
        1. Gyetvai (1999) Obstet Gynecol 94:869-77
    3. Terbutaline
      1. Effective at temporarily stopping contractions
        1. Results in shortest hospital triage stays
        2. Guinn (1997) Am J Obstet Gynecol 177:814-87
      2. Oral Terbutaline is not effective in Preterm Labor
        1. Lewis (1996) Am J Obstet Gynecol 175:834-7
    4. Ritodrine (only FDA approved Preterm Labor Tocolytic)
      1. Not shown to be more effective than Placebo
      2. (1992) N Engl J Med 327:308-12
    5. Indomethacin (Indocin)
      1. Dosing: Start 50-100 mg orally and then maintain at 25-50 mg orally every 4 hours for 48 hours
      2. Not recommended after 32 weeks due to ductus arteriosus constriction
    6. Nifedipine (Procardia)
      1. Start at 30 mg oral loading dose, then 10-20 mg every 4-6 hours
      2. Mixed results on efficacy, however recent studies suggest very effective
  5. References
    1. Berkman (2003) Am J Obstet Gynecol 188:1648-59
    2. Sayres (2010) Am Fam Physician 81(4): 477-84

Tocolysis (C0040348)

Definition (MSH) Any drug treatment modality designed to inhibit UTERINE CONTRACTION. It is used in pregnant women to arrest PREMATURE LABOR.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D015145
SnomedCT 103747003
English Therapies, Tocolytic, Therapy, Tocolytic, Tocolyses, Tocolysis, Tocolytic Therapies, Tocolytic Therapy, Tocolytic Treatment, Tocolytic Treatments, Treatment, Tocolytic, Treatments, Tocolytic, THER TOCOLYTIC, TOCOLYTIC THER, tocolytic therapy, tocolyse, tocolysis, tocolytic treatment, Inhibition of uterine contractions, Tocolysis (procedure)
Swedish Tokolys
Japanese ｼﾞﾝﾂｳﾖｸｾｲ, 子宮収縮抑制, 陣痛抑制, 子宮収縮抑制療法, 出産消散
Czech tokolýza, Tokolýza
Finnish Tokolyysi
Russian RODOVOI DEIATEL'NOSTI SNIZHENIE, TOKOLIZ, TOKOLITICHESKAIA TERAPIIA, РОДОВОЙ ДЕЯТЕЛЬНОСТИ СНИЖЕНИЕ, ТОКОЛИЗ, ТОКОЛИТИЧЕСКАЯ ТЕРАПИЯ
French Thérapie tocolytique, Tocolyse, Traitement tocolytique
Italian Trattamento tocolitico, Terapia tocolitica, Tocolisi
Polish Leczenie tokolityczne, Tokoliza
Hungarian Tocolysis
Spanish inhibición de las contracciones uterinas, tocólisis (procedimiento), tocólisis, Tocolisis, Terapia Tocolitica, Tocólisis, Terapia Tocolítica
Portuguese Tocolise, Terapia Tocolítica, Tocólise
Dutch tocolyse, Therapie, tocolytische, Tocolyse
German Tokolyse, Tokolytische Therapie
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Tocolytic Agents (C0040349)

Definition (CSP) class of drugs which inhibit premature labor.
Definition (MSH) Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
Concepts Pharmacologic Substance (T121)
MSH D015149
SnomedCT 262212007
English Agents, Tocolytic, Tocolytic Agents, Tocolytics, tocolytic agent, tocolytics, tocolytic, drugs tocolytic, tocolytic agents, Tocolytic drug, Tocolytic drug (product), Tocolytic drug (substance)
German Mittel zur Hemmung der Wehentätigkeit, Wehenhemmende Mittel, Wehenhemmer, Tokolysemittel, Tokolytika
French Médicaments tocolytiques, Agents tocolytiques, Tocolytiques
Swedish Tokolytika
Czech tokolytika
Finnish Tokolyytit
Italian Tocolitici, Agenti tocolitici
Russian TOKOLITICHESKIE SREDSTVA, RODOVUIU DEIATEL'NOST' SNIZHAIUSHCHIE SREDSTVA, РОДОВУЮ ДЕЯТЕЛЬНОСТЬ СНИЖАЮЩИЕ СРЕДСТВА, ТОКОЛИТИЧЕСКИЕ СРЕДСТВА
Croatian TOKOLITICI
Polish Leki przeciw skurczom macicy, Środki hamujące poród, Środki hamujące czynność skurczową macicy, Leki tokolityczne
Japanese 陣痛抑制剤, 子宮収縮抑制剤, 子宮収縮抑制薬, 陣痛抑制薬
Spanish fármaco tocolítico (producto), fármaco tocolítico, Agentes Tocoliticos, Agentes Tocolíticos
Portuguese Tocolíticos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Navigation Tree