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Galantamine

Aka: Galantamine, Reminyl, Razadyne

See Also
1. Rivastigmine (Exelon)
2. Donepezil (Aricept)
Indication
1. Alzheimer's Disease related Dementia
Mechanism
1. Acetylcholinesterase inhibitor
2. Acts also at nicotinic receptors
3. Derived from Daffodil bulbs
Pharmacokinetics
1. Half-Life: 7 hours in elderly patients
2. Metabolized by liver enzymes: CYP2D6 and CYP3A4
Dosing
1. Initial: 4 mg PO bid with breakfast and dinner x4 weeks
2. Maintenance: 8 mg PO bid for at least 4 weeks
3. Consider 12 mg PO bid if indicated
4. May require concurrent Antiemetic use
Adverse Effects
1. No hepatic toxicity found (contrast with Tacrine)
2. Gastrointestinal effects
  1. Nausea or Vomiting
  2. Diarrhea
  3. Anorexia
  4. Weight loss
3. Cardiovascular effects
  1. Dizziness
  2. Bradycardia
Efficacy
1. Moderately preserved cognitive function for >6 months
2. References
  1. Raskind (2000) Neurology 54:2261
  2. Tariot (2000) Neurology 54:2269
Cost
1. (2003) Red Book: $134/month
References
1. (2001) Med Lett Drugs Ther 43(1107):53-4

Medication Costs
Galantamine Hydrobromide (on 2/9/2012 at DrugStore.com)
Galantamine Hydrobromide 8mg Tablets	#30 for $69.99	($2.33/unit)
Galantamine Hydrobromide 30 8mg 24 Hour Capsule Bottle	#1 for $118.99	($118.99/unit)
Galantamine Hydrobromide 30 16mg 24 Hour Capsule Bottle	#1 for $119.99	($119.99/unit)
Razadyne (on 2/9/2012 at DrugStore.com)
Razadyne 4mg Tablets	#30 for $109.99	($3.67/unit)
Razadyne 8mg Tablets	#30 for $112.16	($3.74/unit)
Razadyne 12mg Tablets	#30 for $112.16	($3.74/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Galantamine (C0016967)
Definition (MSH)	A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.
Concepts	Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH	D005702
SnomedCT	323377002, 395727007
English	Galantamin, Lycoremine, galanthamine, lycoremine, Galantamine [Chemical/Ingredient], galantamin, galantamine, Galanthamine, 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, Galantamine, Galantamine (product), Galantamine (substance), GALANTAMINE
Swedish	Galantamin
Czech	galanthamin, galantamin
Finnish	Galantamiini
Russian	NIVALIN, LIKOREMIN, GALANTAMIN, ГАЛАНТАМИН, ЛИКОРЕМИН, НИВАЛИН
Japanese	リコレミン, ガランタミン, 臭化水素酸ガランタミン, ガランタミン臭化水素酸塩
Croatian	GALANTAMIN
Polish	Niwalina, Galantamina
Spanish	galantamina (producto), galantamina (sustancia), galantamina, Galantamina, Licoremina, Licorémina
French	Galantamine, Galanthamine
German	Galantamin, Galanthamin, Lycoremin
Italian	Galantamina
Portuguese	Galantamina, Licoremina
Sources	Derived from the NIH UMLS (Unified Medical Language System)

Razadyne (C0939465)
Definition (MSH)	Name of the FDA approved preparation from J&J.
Concepts	Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH	D005702
Czech	reminyl
German	Reminyl
English	Razadyne, Ortho McNeil Neurologics Brand of Galantamine, Ortho-McNeil Neurologics Brand of Galantamine, reminyl, Reminyl
Portuguese	Reminyl
Spanish	Reminilo
Sources	Derived from the NIH UMLS (Unified Medical Language System)