II. Indications
III. Contraindications
- Recent major bleeding
IV. Mechanism
- Inhibits Platelet aggregation via Glycoprotein IIb/IIIa receptors on Platelet plasma membranes
- Inhibits Fibrinogen binding to Platelets
V. Dosing
-
Non-ST elevation Myocardial Infarction (NSTEMI)
- Load: 25 mcg/kg over 5 min
- Infuse: 0.15 mcg/kg/min for up to 18 hours
- Slow rate to 0.075 mcg/kg/min if GFR <=60 ml/min
VI. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation