Hematology and Oncology Book

Coagulopathy

Cancer

Anemia

Hemoglobinopathies

Hemolytic Disorders

Pathology and Laboratory Medicine

Blood Transfusion

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Lymphatic Disorders

Platelet Disorders

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Plant Alkaloid Chemotherapy

Aka: Plant Alkaloid Chemotherapy
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  1. Mechanism
    1. Vinca alkaloids
      1. Inhibits mitosis (metaphase arrest)
      2. Cause disassembly of microtubules
    2. Podophyllotoxins
      1. Block cells in S-G2 phase of cell cycle
      2. DNA degradation
      3. Nucleoside transport inhibition
      4. Mitochondrial electron transport inhibition
  2. Agents
    1. Periwinkle Plant (Vinca rosea) derivative
      1. Vinblastine (Velban)
      2. Vincristine (Oncovin)
    2. Mayapple plant (Podophyllum peltatum) derivative
      1. Etoposide (VP-16)
      2. Teniposide (VM-26)

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