Hematology and Oncology Book

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Leukocyte Morphology on Peripheral Smear

Aka: Leukocyte Morphology on Peripheral Smear, Leukocyte Morphology, White blood Cell morphology, Hypersegmented Neutrophil, Bilobed Neutrophil, Atypical lymphocyte, Toxic granulation, Lymphoblast, Plasmablast, Myeloblast, Promyelocyte, Myelocyte
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  1. See Also
    1. Bone Marrow Exam
    2. Leukocyte
  2. Background
    1. Variants below as seen on Peripheral Smear
  3. Toxic granulation of Neutrophils and Metamyelocytes
    1. Bacterial infections
  4. Atypical lymphocytes
    1. Viral infections
  5. Giant cytoplasmic granules
    1. Chediak-Higashi Syndrome
  6. Bilobed Neutrophils
    1. Pelger-Huet anomaly
  7. Hypersegmented Neutrophils
    1. Pernicious Anemia (Vitamin B12 Deficiency)
    2. Folate Deficiency
    3. Myeloproliferative disease
  8. Myeloblasts, Promyelocytes, Myelocytes
    1. Acute Myeloblastic Leukemia
    2. Acute promyelocytic Leukemia
    3. Chronic myelocytic Leukemia
    4. Myelofibrosis
    5. Polycythemia Vera
  9. Large granular Lymphocytes
    1. T-gamma lymphoproliferative disease
      1. Natural Killer Cells
  10. Lymphoblasts
    1. Acute Lymphoblastic Leukemia
    2. Prolymphocytic Leukemia
    3. Malignant Lymphoma
    4. Chronic Lymphocytic Leukemia
    5. Infectious Mononucleosis
  11. Plasmablasts
    1. Multiple Myeloma

Promyelocytes (C0033416)

Definition (MSH) The cells in the granulocytic series that are derived from myeloblasts and that are the earliest cells of the myelocyte stage.
Definition (NCI) A cell of the bone marrow that is derived from myeloblasts and will give rise to myelocytes, precursors of myeloid cells and neutrophil granulocytes.
Concepts Cell (T025)
MSH D042381
SnomedCT 43446009
English Progranulocyte, NOS, Promyelocyte, NOS, Promyelocytes, promyelocytes, promyelocyte, Premyelocytes, Premyelocyte, Progranulocytes, Promyelocyte, Progranulocyte, Promyelocyte (cell)
French Promyélocyte, Progranulocytes, Promyélocytes
Czech promyelocyty
Portuguese Promielócitos
Spanish Promielocitos, progranulocito, promielocito (célula), promielocito
German Progranulozyten, Promyelozyten
Dutch Promyelocyten
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Atypical lymphocyte (C0221277)

Concepts Cell (T025)
SnomedCT 52641009, 270921005
English Atypical lymphocyte, LYMPHOCYTES ATYPICAL, Reactive lymphocyte, Atypical lymphocytes (cell), Lymphocytes atypical, LYMPHOCYTE ABNORMAL, Lymphocytes.abnormal, atypical lymphocyte, atypical lymphocytes, reactive lymphocyte, lymphocytes reactive, lymphocyte atypical, Atypical Lymphocyte, Atypical lymphocytes, Atypical lymphocyte (morphologic abnormality), Atypical lymphocyte (cell), Atypical lymphocytes (morphologic abnormality), Abnormal Lymphocyte, Reactive Lymphocyte
Dutch atypische lymfocyten, lymfocyten atypisch
French Lymphocytes atypiques, LYMPHOCYTES ATYPIQUES
German atypische Lymphozyten, Lymphozyten atypisch, LYMPHOZYTEN ATYPISCH
Italian Linfociti atipici
Portuguese Linfócitos atípicos, LINFOCITOS ATIPICOS
Spanish Linfocitos atípicos, Atypical lymphocytes, LINFOCITOS ATIPICOS, linfocito atípico (anomalía morfológica), linfocito atípico, linfocito reactivo (anomalía morfológica), linfocito reactivo
Japanese 異型リンパ球, ｲｹｲﾘﾝﾊﾟｷｭｳ
Czech Atypické lymfocyty
Hungarian Atípusos limfociták, Limfociták atípusos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


lymphoblast (C0229613)

Definition (NCI) A lymphocyte that has gotten larger after being stimulated by an antigen. Lymphoblast also refers to an immature cell that can develop into a mature lymphocyte.
Definition (CSP) a morphologically immature lymphocyte, once thought to represent an early stage in lymphocyte development but now known to be an activated lymphocyte that has been transformed in response to antigenic stimulation.
Definition (NCI) An immature lymphocyte that has enlarged in response to antigenic stimulation.
Concepts Cell (T025)
SnomedCT 15433008
English Lymphoblasts, lymphoblasts, lymphoblastic, Lymphoblast, Lymphocytoblast, Lymphoblast (cell), lymphoblast
Spanish linfoblasto (célula), linfoblasto, linfocitoblasto
Sources
Derived from the NIH UMLS (Unified Medical Language System)


myeloblast (C0229633)

Definition (NCI) Refers to myeloblasts (a type of immature cell that forms in the bone marrow).
Definition (NCI) An immature cell that represents the first stage in the granulocytic series of hematopoiesis. It is found in bone marrow and differentiates into a promyelocyte. Its nucleus is composed of very fine, evenly distributed chromatin with 2-5 nucleoli. The cytoplasm is basophilic and non-granular.
Concepts Cell (T025)
MSH D042381
SnomedCT 15622002
French Myéloblaste, Myéloblastes
Czech myeloblasty
Portuguese Mieloblastos
Spanish Mieloblastos, mieloblasto (célula), mieloblasto
German Myeloblasten
English myeloblasts, myeloblastic, Myeloblast, Myeloblast (cell), myeloblast, Myeloblasts
Dutch Myeloblasten
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Plasmablast (cell) (C0229657)

Concepts Cell (T025)
SnomedCT 2579009
English Plasmablast (cell), Plasmablast
Spanish plasmoblasto (célula), plasmoblasto
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Myelocytes (C0369715)

Definition (CSP) precursor in the granulocytic series; in this stage, differentiation into specific cytoplasmic granules has begun.
Definition (NCI) A cell derived from a promyelocyte. It differentiates into a metamyelocyte. It has a diameter of 10-18 micrometer, and an oval or round nucleus with finely granulated chromatin.
Concepts Cell (T025)
MSH D042381
SnomedCT 127915008, 165545002
French Myélocyte, Myélocytes
English Myelocytes, myelocyte, myelocytes, Myelocyte, Myelocyte (cell)
German Myelozyten
Spanish mielocito (célula), mielocito
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Hypersegmented neutrophil (C0483202)

Concepts Cell or Molecular Dysfunction (T049)
SnomedCT 127564008
English NEUTROPHILS, HYPERSEGMENTED, Neutrophils.hypersegmented, hypersegmented neutrophil, hypersegmented neutrophils, Hypersegmented neutrophil (morphologic abnormality), Hypersegmented neutrophil, Hypersegmented neutrophil (cell)
Spanish neutrófilo hipersegmentado (anomalía morfológica), neutrófilo hipersegmentado (célula), neutrófilo hipersegmentado
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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