II. Indications
- HIV Infection (as part of combination therapy)
III. Mechanism
IV. Medications
- Raltegravir tablets: 400 mg
- Raltegravir HD tablets: 600 mg (use 2 for 1200 mg daily dose)
- Raltegravir single use powder packets for suspension: 100 mg/5 ml (when reconstituted)
- Raltegravir chewable tablets (with Phenylalanine): 25 and 100 mg
V. Dosing: Adult (or child weight>=25 kg)
VI. Dosing: Child (weight <25 kg)
- FDA approved for newborns (including weight guidelines down to 2 kg)
- See other dosing references for pediatric dosing
VII. Adverse Effects
- Rhabdomyolysis (or mopathy)
- Hypersensitivity Reactions and severe rashses (e.g. Stevens Johnson Syndrome)
VIII. Safety
IX. Drug Interactions
-
Rifampin
- increase dose to 800 mg orally twice daily
- Medications that interfere with absorption (take Dolutegravir 2 hours before or 6 hours after these agents)
- Medications contraindicated with Dolutegravir HD (daily dosing formulation)
- Entravirine
- Rifampin
- Tipranavir/r
X. Pharmacokinetics
- Excretion via Glucuronidation
- Avoid before Hemodialysis
XI. Resources
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Related Studies
| isentress (on 1/6/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ISENTRESS 400 MG TABLET | $29.50 each | |
| ISENTRESS HD 600 MG TABLET | $29.57 each | |
| ral (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| RALOXIFENE HCL 60 MG TABLET | Generic | $0.28 each |