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Sequential Estrogen Replacement

Aka: Sequential Estrogen Replacement, Cyclic Estrogen Replacement

See Also
Protocol
1. Estrogen taken daily
2. Progestin taken for 2 weeks of each month
  1. First 2 weeks of month may be better remembered
Preparations: Estrogens Options (choose one to accompany a Progesterone)
1. Conjugated Estrogen (Premarin) 0.625mg orally daily
2. Estropipate (Ogen) 0.625 orally daily
3. Esterified Estrogen (Estratab) 0.625 orally daily
4. Estradiol (Estrace) 0.5 mg orally daily
5. Transdermal Estrogen (must be an Estrogen only product if used sequentially)
  1. Example: Estradiol transdermal (Estraderm) 0.05 mg patch/week
Preparations: Progestin Options (choose one to accompany an Estrogen)
1. First line:
  1. Provera 5 mg orally daily for 2 weeks of each month
2. Second line (refractory to Provera)
  1. Norethindrone orally daily for 2 weeks of each month
  2. Micronized Progesterone 200 ug orally daily for 2 weeks of each month
Adverse Effects
1. Cyclic withdrawal bleed in 80-90% within 6 months

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 10/31/2008 and last published on 5/14/2013.

This is one of 5887 pages in the Family Practice Notebook