II. Definitions

  1. Premature Ejaculation
    1. Persistent or recurrent semen or seminal fluid emission before or shortly after sexual penetration
    2. Ejaculatory latency typically is less than 1 minute from time of sexual penetration

III. Epidemiology

  1. Affects 4 to 39% of men

IV. Causes

  1. Sexual Performance Anxiety
  2. Sexual relationship problems
  3. Mental Health Disorders
  4. Erectile Dysfunction
  5. Medication Withdrawal
  6. Recreational Drug Withdrawal
  7. Prostatitis (rare cause)
  8. Hyperthyroidism (rare cause)

V. Complications

  1. Personal distress
  2. Avoidance of sexual intimacy

VI. Management: Non-Pharmacologic

  1. Behavioral Therapy (e.g. psychosexual counseling, psychotherapy, cognitive distraction, Hypnotherapy)
  2. Meditation and other Relaxation Techniques
  3. Precoital masturbation
  4. Increased frequency of sex
  5. Alternate sexual positions
  6. Extended foreplay
  7. Pelvic Floor Exercises
  8. Stop-start and squeeze techniques to delay ejaculation
  9. Multiple Condoms worn

VII. Management: Pharmacologic

  1. Topical Anesthetic cream
  2. Antidepressants (esp. SSRI, SNRI) - Effective but high discontinuation rate for side effects
    1. Clomipramine (Anafranil, Tricyclic Antidepressant)
    2. Dapoxetine (Priligy)
    3. Paroxetine (Paxil)
    4. Sertraline (Zoloft)
    5. Citalopram (Celexa)
    6. Fluoxetine (Prozac)
    7. Sathianathen (2021) Cochrane Database Syst Rev (3):CD012799 [PubMed]

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Ontology: Premature Ejaculation (C0033038)

Definition (MSH) The emission of SEMEN and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration.
Definition (NCI) A disorder characterized by persistent or recurrent ejaculation before or after penetration and before the person wishes it.
Concepts Mental or Behavioral Dysfunction (T048)
MSH D061686
ICD9 302.75
ICD10 F52.4
SnomedCT 123302009, 192468006, 268762007, 154905005, 44001008
DSM4 302.75
English EJACULATION PREMATURE, premature ejaculation, premature ejaculation (symptom), premature ejaculation (diagnosis), Premature ejaculation disorder, Ejaculation premature, ejaculatio praecox, ejaculation premature, Premature;ejaculation, ejaculations premature, premature ejaculation disorder, Premature Ejaculation, Ejaculatio Praecoxs, Praecox, Ejaculatio, Ejaculations, Premature, Premature Ejaculations, Praecoxs, Ejaculatio, Ejaculation, Premature, Ejaculatio Praecox, Premature Ejaculation [Disease/Finding], Premature ejaculation (disorder), Premature ejaculation, Ejaculatio praecox, Ejaculates too soon, Premature orgasm - male, Premature ejaculation (finding), dysfunction; sexual, premature ejaculation, ejaculation; premature, praecox; ejaculation, premature; ejaculation, sexual; functional disturbance, premature ejaculation, Premature ejaculation -RETIRED-
Italian Eiaculazione precoce, Disturbo da eiaculazione precoce, Ejaculatio Praecox, Eiaculazioe precoce
Dutch voortijdige ejaculatiestoornis, ejaculatie voortijdig, ejaculatie; prematuur, functiestoornis; seksueel, ejaculatio praecox, praecox; ejaculatie, prematuur; ejaculatie, seksueel; functiestoornis, ejaculatio praecox, Ejaculatio praecox, voortijdige ejaculatie
French Ejaculation prématurée, Trouble de l'éjaculation précoce, EJACULATION PRECOCE, Éjaculation précoce, Ejaculatio praecox, Éjaculation prématurée, Ejaculation précoce
German Ejakulation vorzeitig, Ejakulationsstoerung vorzeitig, EJAKULATIO PRAECOX, Vorzeitige Ejakulation, Vorzeitiger Samenerguss, Ejaculatio praecox, vorzeitige Ejakulation
Portuguese Perturbação de ejaculação precoce, EJACULACAO PRECOCE, Ejaculação Precoce, Ejaculação Prematura, Ejaculação precoce
Spanish Eyaculación prematura, Trastorno de eyaculación precoz, EYACULACION PRECOZ, Eyaculación Prematura, eyaculación precoz - RETIRADO - (concepto no activo), eyaculación precoz - RETIRADO -, ejaculatio praecox, eyaculación precoz (hallazgo), eyaculación precoz, Eyaculación precoz
Japanese 早漏, 早漏性障害, ソウロウセイショウガイ, ソウロウ
Czech Předčasná ejakulace, Porucha s předčasnou ejakulací, Ejakulace předčasná, předčasná ejakulace
Korean 조루증
Hungarian Korai ejaculatio, Korai ejaculatiós zavar
Polish Przedwczesny wytrysk, Wytrysk przedwczesny, Ejakulacja przedwczesna
Russian ПРЕЖДЕВРЕМЕННАЯ ЭЯКУЛЯЦИЯ, PREZHDEVREMENNAIA EIAKULIATSIIA, ПРЕЖДЕВРЕМЕННОЕ СЕМЯИЗВЕРЖЕНИЕ, PREZHDEVREMENNOE SEMIAIZVERZHENIE
Norwegian Prematur sædavgang, Ejaculatio Praecox