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Ontology:
Finasteride
(C0060389)
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Definition (MSH)
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An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.
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Definition (NCI)
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A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation.
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Definition (NCI_NCI-GLOSS)
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A drug used to reduce the amount of male hormone (testosterone) produced by the body.
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Definition (CSP)
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orally active testosterone 5-alpha reductase inhibitor, used as an alternative to surgery for treatment of benign prostatic hyperplasia.
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Definition (PDQ)
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A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41096&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41096&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1099" NCI Thesaurus)
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| Concepts |
Hormone
(T125)
, Pharmacologic Substance
(T121)
, Steroid
(T110)
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| MSH |
D018120
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| SnomedCT |
109035006, 386963006 |
| LNC |
LP101034-9, MTHU036233 |
| English |
Finasteride, 4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-, (5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, finasteride, finasteride (medication), FINASTERIDE, Finasteride [Chemical/Ingredient], finasteride products, Finasteride (product), Finasteride (substance) |
| Swedish |
Finasterid
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| Czech |
finasterid
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| Finnish |
Finasteridi
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| Russian |
FINASTERID, ФИНАСТЕРИД |
| Japanese |
フィナステリド
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| Polish |
Finasteryd
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| Spanish |
Finasteride, finasterida (producto), finasterida (sustancia), finasterida, Finasterida |
| Portuguese |
Finasteride, Finasterida |
| French |
Finastéride
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| German |
Finasterid
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| Italian |
Finasteride
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Ontology:
Proscar
(C0678149)
| Concepts |
Pharmacologic Substance
(T121)
, Steroid
(T110)
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| MSH |
D018120
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| English |
finasteride (Proscar), proscar, Proscar, Cahill May Roberts Brand of Finasteride, MSD Chibropharm Brand of Finasteride, Merck Brand 2 of Finasteride, Merck Frosst Brand 2 of Finasteride, Merck Sharp & Dhome Brand 2 of Finasteride |
Ontology:
Propecia
(C0722858)
| Concepts |
Steroid
(T110)
, Pharmacologic Substance
(T121)
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| MSH |
D018120
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| English |
finasteride (Propecia), propecia, Propecia, Propeshia, MSD Brand of Finasteride, Merck Brand 1 of Finasteride, Merck Frosst Brand 1 of Finasteride, Merck Sharp & Dohme Brand 1 of Finasteride |
Ontology:
Dutasteride
(C0754659)
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Definition (NCI)
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A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.
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Definition (NCI_NCI-GLOSS)
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A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor.
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Definition (PDQ)
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A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5-alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5-alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5-alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=479183&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=479183&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47503" NCI Thesaurus)
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| Concepts |
Steroid
(T110)
, Pharmacologic Substance
(T121)
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| MSH |
C108373
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| SnomedCT |
408009000, 385570006, 385572003 |
| English |
DUTASTERIDE @ @ UNIDENTIFIED, DUTASTERIDE UNIDENTIFIED, alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide, Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, 17beta-N-(2,5-bis(trifluoromethyl))phenyl-carbamoyl-4-aza-5alpha-androst-1-en-3-one, dutasteride (medication), DUTASTERIDE, dutasteride [Chemical/Ingredient], Dutasteride, Dutasteride (product), Dutasteride (substance), dutasteride |
| Spanish |
dutasterida (producto), dutasterida (sustancia), dutasterida |
Ontology:
5-alpha Reductase Inhibitor [EPC]
(C1318898)
| Concepts |
Pharmacologic Substance
(T121)
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| English |
5-alpha Reductase Inhibitor, 5-alpha Reductase Inhibitor [EPC] |
