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Ontology:
anakinra
(C0245109)
Definition (NCI)
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A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist.
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Definition (MSH)
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A synthetic form of native human IL-1Ra that has an additional methionine residue at its amino terminus.
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Definition (PDQ)
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A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43007&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43007&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38717" NCI Thesaurus)
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Concepts |
Amino Acid, Peptide, or Protein
(T116)
, Pharmacologic Substance
(T121)
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MSH |
D053590
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SnomedCT |
395279009, 385549000 |
English |
Anakinra, anakinra (medication), Anakinra (obsolete), Anakinra [Chemical/Ingredient], rIL-1ra, rIL1RN, Kinaret, anakinra, Anakinra (product), Anakinra (substance), ANAKINRA |
French |
Anakinra
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German |
Anakinra
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Czech |
anakinra
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Japanese |
アナキンラ
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Spanish |
anakinra (producto), anakinra (sustancia), anakinra |
Ontology:
Kineret
(C1170364)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D053590
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English |
Kineret, Amgen Brand of Anakinra, Anakinra Amgen Brand, kineret |
French |
Kineret
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German |
Kineret
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Czech |
Kineret
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