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Ontology:
Etanercept
(C0717758)
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Definition (NCI)
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A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A drug that is commonly used to treat arthritis. It is also being studied in the treatment of cancer, and as a treatment for loss of appetite and weight loss in cancer patients. It belongs to the family of drugs called tumor necrosis factor (TNF) antagonists.
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Definition (PDQ)
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A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257809&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257809&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2381" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Immunologic Factor
(T129)
, Amino Acid, Peptide, or Protein
(T116)
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| MSH |
C106167
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| SnomedCT |
118259007, 387045004 |
| English |
Tumor Necrosis Factor Receptor IgG Chimera, tumor necrosis factor receptor IgG chimera, etanercept (medication), ETANERCEPT, Etanercept, Etanercept (product), Etanercept (substance), TNFR:Fc, etanercept, ETN |
| Spanish |
etanercept (producto), etanercept (sustancia), etanercept |
Ontology:
Enbrel
(C0720193)
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Definition (CHV)
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brand name of a drug that is used to treat rheumatism
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Definition (CHV)
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brand name of a drug that is used to treat rheumatism
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| Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
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| MSH |
C106167
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| English |
Enbrel, etanercept (Enbrel), enbrel [brand name], enbrel, Immunex brand of etanercept, Wyeth brand of etanercept |
