Etanercept

Aka: Etanercept, Enbrel

II. Indication

  1. Refractory Rheumatoid Arthritis
    1. Combined with Methotrexate and other DMARDs
    2. Corticosteroid sparing in agents
  2. Juvenile Rheumatoid Arthritis
  3. Psoriatic Arthritis

III. Mechanism

  1. Soluble TNF receptor blocker

IV. Efficacy

  1. Rapid onset and very effective
  2. Arrests XRay progression
  3. Good synergistic effect with Methotrexate

V. Adverse Effects

  1. Potential risk of infection
  2. No significant adverse effects

VI. Dosing

  1. Preloaded vial or syringe: 25 mg SQ twice weekly or 50 mg SC weekly

VII. Cost

  1. Per vial: $150
  2. Per month: $1200
  3. Per year: $14,000

VIII. Monitoring

  1. Consider following Complete Blood Count

IX. References

  1. Bathon (2000) N Engl J Med 343:1586-93 [PubMed]
  2. Weinblatt (1999) N Engl J Med 340: 253-9 [PubMed]

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Related Studies

Cost: Medications

enbrel (on 1/20/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
ENBREL 25 MG KIT $541.08 each
ENBREL 25 MG/0.5 ML SYRINGE $1,059.98 per ml
ENBREL 50 MG/ML SURECLICK SYR $1,096.52 per ml
ENBREL 50 MG/ML SYRINGE $1,097.70 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: Etanercept (C0717758)

Definition (NCI) A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)
Definition (NCI_NCI-GLOSS) A drug that is commonly used to treat arthritis. It is also being studied in the treatment of cancer, and as a treatment for loss of appetite and weight loss in cancer patients. It belongs to the family of drugs called tumor necrosis factor (TNF) antagonists.
Definition (PDQ) A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257809&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257809&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2381" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129) , Amino Acid, Peptide, or Protein (T116)
MSH C106167
SnomedCT 118259007, 387045004
English Tumor Necrosis Factor Receptor IgG Chimera, tumor necrosis factor receptor IgG chimera, etanercept (medication), ETANERCEPT, Etanercept, Etanercept (product), Etanercept (substance), TNFR:Fc, etanercept, ETN
Spanish etanercept (producto), etanercept (sustancia), etanercept
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Enbrel (C0720193)

Definition (CHV) brand name of a drug that is used to treat rheumatism
Definition (CHV) brand name of a drug that is used to treat rheumatism
Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116)
MSH C106167
English Enbrel, etanercept (Enbrel), enbrel [brand name], enbrel, Immunex brand of etanercept, Wyeth brand of etanercept
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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