II. Indications

  1. Acute back or Neck Pain interfering with sleep despite Analgesics

III. Class

  1. Antispasmodic Skeletal Muscle Relaxant

IV. Dosing

  1. Start: 5 mg orally at bedtime (5 mg is as effective as 10 mg and with less sedation)
  2. Maximum: 10 mg orally three times daily (primarily at bedtime for pain interfering with sleep)

V. Contraindications

  1. Older patients
    1. See Medications to Avoid in Older Adults
  2. Seizure disorder (if concurrently on Tramadol)
  3. Glaucoma
  4. Cardiac arrhythmia
  5. Congestive Heart Failure
  6. Recent Myocardial Infarction

VI. Efficacy

  1. See Antispasmodic Skeletal Muscle Relaxant

VII. Adverse effects

  1. See Antispasmodic Skeletal Muscle Relaxant for precautions
  2. Common: Anticholinergic
    1. Drowsiness
    2. Dry Mouth
    3. Urinary Retention
    4. Increased Intraocular Pressure
  3. Rare
    1. Arrhythmia
    2. Seizure
    3. Myocardial Infarction

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Related Studies

Cost: Medications

Cyclobenzaprine (on 6/18/2017 at Walmart.com)
Cyclobenzaprine 10mg #30 tablets for $4.00 $0.13 each
Cyclobenzaprine 10mg #90 tablets for $10.00 $0.11 each
Cyclobenzaprine 5mg #30 tablets for $4.00 $0.13 each
Cyclobenzaprine 5mg #90 tablets for $10.00 $0.11 each
cyclobenzaprine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)

Ontology: cyclobenzaprine (C0056732)

Definition (NCI) A centrally acting skeletal muscle relaxant with antidepressant activity. The exact mechanism of action of cyclobenzaprine has not been fully determined, but this drug seems to primarily act at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons leading to a reduction in muscle spasms.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C004704
SnomedCT 373779004, 80802008
LNC LP17189-9, MTHU004256
English cyclobenzaprine, N,N-dimethyl-3-(dibenzo(a,d)cycloheptene-4-ylidene)propylamine, cyclobenzaprine [Chemical/Ingredient], CYCLOBENZAPRINE, Cyclobenzaprine, Cyclobenzaprine (product), Cyclobenzaprine (substance)
Spanish ciclobenzaprina (producto), ciclobenzaprina (sustancia), ciclobenzaprina