II. Physiology

  1. Peptide Hormone, secreted by parafollicular cells of the Thyroid Gland
    1. Secreted in response to Hypercalcemia
  2. Lowers Serum Calcium levels (esp. in children)
    1. Decreases Osteoclast formation and bone resorptive activity (bone breakdown)
    2. Increases renal Calcium excretion
    3. Weakly opposes Parathyroid Hormone

III. Indications: Osteoporosis

  1. Weak Osteoporosis Management alternative for women not on Estrogen Replacement
  2. Painful Vertebral osteoporotic Fracture

IV. Efficacy

  1. Not as effective as Estrogen Replacement
  2. Reduces Vertebral Fractures 30-60% for >2 years
  3. Increases BMD of spine 3% in osteoporotic women

V. Preparations

  1. Calcitonin-Salmon
    1. Dosing: 100 IU SQ/IM daily ($195/mo)
  2. Miacalcin
    1. Dosing: 200 IU (1 spray) intranasally daily in alternating nares ($50/mo)

VI. Precautions

  1. Anaphylaxis risk (use test dose in clinic)
  2. Possible increased risk of cancer

VII. Adverse Effects

  1. Skin Flushing
  2. Skin rash
  3. Nausea
  4. Dizzy

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Related Studies

Cost: Medications

calcitonin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CALCITONIN-SALMON 200 UNITS SP Generic $10.41 per ml

Ontology: Calcitonin (C0006668)

Definition (MSH) A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Definition (CSP) a peptide hormone secreted by the parafollicular cells of the thyroid gland in response to hypercalcemia, which lowers blood calcium and phosphate by promoting renal excretion; chemotherapy for Paget's disease and severe hypercalcemia.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D002116
SnomedCT 373474005, 63730009
LNC LP14649-5, MTHU003443
English Calcitonin, Calcitonin(1-32), Calcitrin, Thyrocalcitonin, calcitonin, thyrocalcitonin, Calcitonin [Chemical/Ingredient], calcitonins, Calcitonin agent, Calcitonin agent (substance), CT - Calcitonin, Calcitonin (substance), CALCITONIN
Portuguese Tireocalcitonina, Tirocalcitonina, Calcitonina
Swedish Kalcitonin
Czech kalcitonin
Finnish Kalsitoniini
French TCT (Thyrocalcitonin), Calcitonine, Thyrocalcitonine
Italian Tirocalcitonina, Calcitrin, Calcitonina
Japanese カルシトニン, チロカルシトニン, カルチトニン
Polish Tyreokalcytonina, Kalcytonina
Norwegian Kalsitonin, Calcitrin, Calcitonin(1-32), Thyreocalcitonin
Spanish agente con calcitonina, agente con calcitonina (sustancia), calcitonina (sustancia), calcitonina, tirocalcitonina, Calcitonina, Tirocalcitonina
German Calcitonin, Kalzitonin, Thyrocalcitonin