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Ontology:
pamidronate
(C0043603)
Definition (NCI_NCI-GLOSS)
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A drug that is used to treat hypercalcemia (too much calcium in the blood) and cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.
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Definition (NCI)
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An amino- bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Pamidronic acid binds to and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, pamidronic acid decreases bone turnover rate, stabilizes the bone matrix and reduces hypercalcemia.
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Definition (PDQ)
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A synthetic bisphosphonate agent. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39149&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39149&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1345" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C019248
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SnomedCT |
420481001, 96288007 |
English |
(3-amino-1-hydroxypropylidene)-1,1-biphosphonate, (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate, amino-1-hydroxypropane-1,1-diphosphonate, aminohydroxypropylidene diphosphonate, aminopropanehydroxydiphosphonate, APD, amidronate, Pamidronic Acid, 1-hydroxy-3-aminopropane-1,1-diphosphonic acid, pamidronate [Chemical/Ingredient], apd, apds, AHPrBP, PAMIDRONIC ACID, Pamidronate, Pamidronate (substance), PAMIDRONATE, pamidronate |
Spanish |
ácido pamidrónico, ácido pamidrónico (producto), ácido pamidrónico (sustancia), pamidronato (sustancia), pamidronato |
Ontology:
Etidronate
(C0086268)
Definition (CSP)
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ethane-1-hydroxy-1,1-diphosphonate; a diphosphonate compound that affects calcium metabolism and inhibits the resorption and deposition of hydroxyapatite crystals in bone.
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Concepts |
Organophosphorus Compound
(T115)
, Pharmacologic Substance
(T121)
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MSH |
D012968
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SnomedCT |
49791005, 96284009, 372908005 |
English |
1 Hydroxyethane 1,1 Diphosphonate, 1 Hydroxyethylidene 1,1 Bisphosphonate, 1-Hydroxyethane-1,1-Diphosphonate, 1-Hydroxyethylidene-1,1-Bisphosphonate, EHDP, Ethanehydroxydiphosphonate, Ethanehydroxyphosphate, Etidronate, HEDP, Hydroxyethanediphosphonate, 1,1-hydroxyethylenediphosphonate, etidronate, Etidronate (product), Etidronate [Chemical/Ingredient], ehdp, 1,1 hydroxyethylenediphosphonate, Etidronate (substance), Etidronate -RETIRED-, ETIDRONATE |
Czech |
EHDP, etidronát, ethanhydroxydifosfonát |
Portuguese |
Etidronato, EHDP, Etanoidroxidifosfonato |
Spanish |
Etidronato, etidronato (producto), etidronato-RETIRADO- (concepto no activo), etidronato-RETIRADO-, etidronato (sustancia), etidronato, EHDP, Etanohidroxidifosfonato |
German |
Etidronat, EHDP, Ethanhydroxydiphosphonat |
French |
Étidronate
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Ontology:
Alendronate
(C0102118)
Definition (CHV)
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a drug used to prevent or treat osteoporosis
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Definition (CSP)
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bone resorption inhibitor.
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Definition (MSH)
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A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
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Concepts |
Pharmacologic Substance
(T121)
, Organophosphorus Compound
(T115)
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MSH |
D019386
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SnomedCT |
96290008
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LNC |
LP171384-3 |
English |
alendronate, Alendronate, Aminohydroxybutane Bisphosphonate, Bisphosphonate, Aminohydroxybutane, AHBUTBP, (4-Amino-1-hydroxybutylidene)bisphosphonic Acid, Alendronate [Chemical/Ingredient], 4 Amino 1 Hydroxybutylidene 1,1 Biphosphonate, 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate, Alendronate (substance), ALENDRONATE |
Swedish |
Alendronat
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Czech |
alendronát
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Finnish |
Alendronaatti
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Russian |
ALENDRONAT, АЛЕНДРОНАТ |
Japanese |
アレンドロン酸, アレンドロナート, アレンドロネート |
Polish |
Alendronian
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Spanish |
alendronato (sustancia), alendronato, Alendronato |
French |
Alendronate
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German |
Alendronat
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Italian |
Alendronato
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Portuguese |
Alendronato
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Ontology:
Aredia
(C0104018)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C019248
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English |
Novartis brand of pamidronate disodium salt, Aredia, aredia |
Ontology:
Tiludronate
(C0145942)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C058651
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SnomedCT |
422263009, 96286006 |
English |
(chloro-4-phenyl)thiomethylene biphosphonate, (chloro-4-phenyl)thiomethylene bisphosphonate, TILUDRONATE, Tiludronate, Tiludronate (substance), tiludronate |
Japanese |
チルドロン酸
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Spanish |
tiludronato (sustancia), tiludronato |
Ontology:
Risedronate
(C0246719)
Definition (PDQ)
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A synthetic pyridinyl bisphosphonate agent. Risedronate binds to hydroxyapatite crystals in bone and inhibits osteoclast-dependent bone resorption Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256445&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256445&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1528" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C073008
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SnomedCT |
96289004, 387582001 |
LNC |
LP171635-8 |
English |
2-(3-pyridinyl)-1-hydroxyethylidenebisphosphonate, RISEDRONATE, Risedronate (product), RISEDRONATE SODIUM ANHYDROUS, Risedronate, Risedronate (substance), RISE, risedronate, 2-(3-pyridinyl)-1-hydroxyethylidene-bisphosphonate |
Spanish |
risedronato (producto), risedronato (sustancia), risedronato |
Ontology:
Fosamax
(C0376569)
Concepts |
Pharmacologic Substance
(T121)
, Organophosphorus Compound
(T115)
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MSH |
D019386
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French |
Fosamax
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English |
fosamax, Fosamax |
Ontology:
Ibandronate
(C0379199)
Definition (PDQ)
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A synthetic nitrogen-containing bisphosphonate. Ibandronate inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=365963&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=365963&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1670" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C073007
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SnomedCT |
96287002
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English |
1-hydroxy-3-(methylpentylamino)propylidenebisphosphonate, (1-hydroxy-3-(methylpentylamino)propylidene)bisphosphonate, Ibandronate (substance), Ibandronate, ibandronate, IBANDRONATE |
Spanish |
ibandronato (sustancia), ibandronato |
Ontology:
Didronel
(C0591373)
Concepts |
Pharmacologic Substance
(T121)
, Organophosphorus Compound
(T115)
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MSH |
D012968
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English |
didronel, Didronel |
Ontology:
Skelid
(C0592793)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C058651
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English |
Skelid
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Ontology:
Actonel brand of risedronate sodium
(C0718248)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C073008
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English |
actonel, Actonel brand of risedronate sodium, Actonel, Aventis brand of risedronic acid, monosodium salt, Procter & Gamble Pharmaceuticals brand of risedronic acid, monosodium salt, Procter & Gamble brand of risedronic acid, monosodium salt |
Ontology:
Boniva
(C1541222)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C073007
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English |
Boniva
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