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Ontology:
adalimumab
(C1122087)
Definition (NCI)
|
A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.
|
Concepts |
Pharmacologic Substance
(T121)
, Immunologic Factor
(T129)
, Amino Acid, Peptide, or Protein
(T116)
|
MSH |
C453439
|
SnomedCT |
398728003, 407317001 |
LNC |
LP173592-9, MTHU047400 |
English |
adalimumab (medication), tumor necrosis factor alpha blockers adalimumab, ADALIMUMAB, adalimumab [Chemical/Ingredient], antibody d2e7, Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer, D2E7, adalimumab, D2E7 antibody, Adalimumab (product), Adalimumab, Adalimumab (substance) |
Spanish |
adalimumab (producto), adalimumab, adalimumab (sustancia) |
Ontology:
Humira
(C1171255)
Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
, Immunologic Factor
(T129)
|
MSH |
C453439
|
LNC |
LA16779-3 |
English |
Humira, adalimumab (Humira), humira, Abbott brand of adalimumab |