II. Pathophysiology

  1. Cross-over syndrome of Polymyositis or Dermatomyositis with other Connective Tissue Disorders

III. Signs

  1. Fever
  2. Nonerosive Arthritis
  3. Raynaud Phenomenon
  4. Interstitial Lung Disease
  5. Distal Fingertip fissures (mechanic's hands)

IV. Labs

  1. See Polymyositis and Dermatomyositis
  2. Screening
    1. Antinuclear Antibody
  3. Confirmation
    1. Myositis specific antibodies (of which Anti-Jo-1 Antibody is most sensitive) are only positive in 20% of cases

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Ontology: Antisynthetase syndrome (C2609059)

Concepts Disease or Syndrome (T047)
MSH C537778
SnomedCT 445187004
Spanish Síndrome antisintetasa, síndrome antisintetasa, síndrome antisintetasa (trastorno)
Portuguese Síndrome Antisintetase
Dutch antisynthetasesyndroom
Italian Sindrome antisintetasi
French Syndrome des antisynthétases
German Antisynthetase-Syndrom
Czech Syndrom antisynthetázy
Japanese 抗合成酵素症候群, コウゴウセイコウソショウコウグン
English Antisynthetase syndrome (disorder), Antisynthetase syndrome
Hungarian Antisynthetáz syndroma