II. Causes: Exogenous Causes

  1. See medications and toxins below
  2. Limb ischemia
  3. Trauma or Poisoning
    1. Lightning Injury, Electrocution or third-degree burns
    2. Compartment Syndrome
    3. Crush injury
    4. Snake Bite
    5. Africanized honey bee bites
    6. Carbon Monoxide Poisoning
    7. Prolonged immobility (patient found down)
  4. Heat Injury
    1. Heat Stroke
    2. Malignant Hyperthermia
    3. Neuroleptic Malignant Syndrome
  5. Physical exertion
    1. Marathon Running
    2. Overexertion
      1. Deconditioned athletes
      2. Sickle Cell Anemia
    3. Exercising with impaired heat dissipation
      1. Heavy or occlusive sports equipment
      2. Humid, warm environment

V. Causes: Alcohol or Drug Use

VI. References

  1. Marx in Rosen (2002) Emergency Medicine 1762-70
  2. Rendon and Opfer (2019) Crit Dec Emerg Med 33(10): 3-8
  3. Sauret (2002) Am Fam Physician 65(5):907-12 [PubMed]

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Ontology: Rhabdomyolysis (C0035410)

Definition (CHV) a potentially fatal disease that destroys skeletal muscle
Definition (MSH) Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
Concepts Pathologic Function (T046)
MSH D012206
ICD9 728.88
ICD10 M62.82
SnomedCT 268106003, 156729009, 311511000009102, 240131006, 89010004
English Rhabdomyolyses, Rhabdomyolysis, RHABDOMYOLYSIS, rhabdomyolysis, rhabdomyolysis (diagnosis), Rhabdomyolysis [Disease/Finding], Necrosis of skeletal muscle, Skeletal muscle necrosis, Necrosis of skeletal muscle (finding), Rhabdomyolysis (disorder), Rhabdomyolysis (morphologic abnormality)
French RHABDOMYOLYSE, Rhabdomyolyse
Portuguese RABDOMIOLISE, Rabdomiólise
Spanish RABDOMIOLISIS, rabdomiólisis (anomalía morfológica), rabdomiólisis, Rabdomiolisis, rabdomiólisis (trastorno), Rabdomiólisis
German RHABDOMYOLYSE, Rhabdomyolyse
Swedish Rabdomyolys
Czech rabdomyolýza, rhabdomyolýza, Rabdomyolýza
Finnish Rabdomyolyysi
Croatian Not Translated[Rhabdomyolysis]
Polish Liza mięśni prążkowanych, Rabdomioliza
Japanese 横紋筋融解症, オウモンキンユウカイショウ
Hungarian Rhabdomyolysis
Norwegian Rabdomyolyse
Dutch rabdomyolyse, Myolyse, rabdo-, Rabdomyolyse
Italian Rabdomiolisi