II. Indication

III. Class

  1. Short Acting Benzodiazepine

IV. Dose

  1. Adult: 0.125 to 0.5 mg PO qhs
  2. Elderly: 0.125 mg PO qhs

V. Pharmacokinetics

  1. Half-Life: 1.5-5.5 hours

VI. Background

  1. Weekly cost: $4.08

VII. Precautions

  1. Reports of Psychosis and Violence
    1. Associated with high dose Halcion (>1 mg)
  2. Likely to be as safe as other Benzodiazepines

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Related Studies

Cost: Medications

triazolam (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
TRIAZOLAM 0.125 MG TABLET Generic $1.28 each
TRIAZOLAM 0.25 MG TABLET Generic $1.27 each
halcion (on 6/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
HALCION 0.25 MG TABLET Generic $1.27 each

Ontology: Triazolam (C0040879)

Definition (NCI) A triazolobenzodiazepinederivative with sedative-hypnotic property. Triazolam interacts directly with a specific site on the gamma-aminobutyric acid (GABA)-A-chloride-ionophore receptor complex located on the neuronal membrane. Binding causes allosteric modification of the receptor and modulation of its affinity for the inhibitory neurotransmitter GABA. This results in enhancement of synaptic actions of GABA and includes an increase in the frequency of chloride channel openings, increased chloride ion conductance, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability.
Definition (CSP) 8-chloro-6-(2-chlorophenyl)-1-methyl- 1,2,4-triazolobenzodiazepine.
Definition (MSH) A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014229
SnomedCT 111128007, 386984001
LNC LP16298-9, MTHU003366
English Triazolam, 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-, triazolam, clorazolam, triazolam (medication), sedatives triazolam, TRIAZOLAM, Triazolam [Chemical/Ingredient], 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine, Clorazolam, Triazolam (product), Triazolam (substance)
Swedish Triazolam
Czech triazolam
Finnish Triatsolaami
Japanese トリアゾラム
Polish Triazolam
Spanish triazolam (producto), triazolam (sustancia), triazolam, Triazolam
French Triazolam
German Triazolam
Italian Triazolam
Portuguese Triazolam

Ontology: Halcion (C0733624)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014229
English Pfizer Brand of Triazolam, Triazolam Pfizer Brand, halcion, Halcion