II. Indications
- Narcotic Toxicity requiring frequent Naloxone dosing
III. Precautions
- Do not use as first line agent for Narcotic Toxicity
- Risk of severe Narcotic Withdrawal
IV. Pharmacokinetics
- Long acting Opioid antagonist
- Duration: 4-8 hours
V. Dosing
-
Opioid Overdose
- Initial: 0.5 mg per 70 kg person IV
- Later: 1 mg per 70 kg IV prn 5 min after initial dose
- Narcotic dependent: 0.1 mg per 70 kg test dose
- Post-operative Narcotic reversal
- Dose: 0.25 ug/kg IV q2-5 minutes
- Maximum: 1 ug/kg total dose
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Related Studies
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C038981 |
| SnomedCT | 109098006 |
| English | 6-desoxy-6-methylenenaltrexone, nalmefene, NALMEFENE, nalmefene [Chemical/Ingredient], Nalmefene (substance), Nalmefene |
| Spanish | nalmefeno (sustancia), nalmefeno |
Ontology: Revex (C0723050)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C038981 |
| English | Revex, nalmefene hydrochloride (Revex), revex |
