II. Indications
III. Mechanism
- Potentiates GABA neurotransmitters
IV. Adverse Effects
- Serious Extrapyramidal Side Effects
- Excessive sedation when used with other CNS Depressants
- May exacerbate Parkinson's Disease
- Platelet Dysfunction
- Dermopathy or Photosensitivity
- Pruritic Red Papules and Plaques
- May be related to Sun Exposure after kava ingestion
- Hepatotoxicity
- Unclear mechanism and incomplete data
- Some cases progressed to liver failure
- Anke (2004) Planta Med 70(3):193-6 [PubMed]
V. Drug Interactions
- Multiple Cytochrome P450 interactions
- Additive effects with CNS Depressants
- Benzodiazepines
- Barbiturates
- Antipsychotics
- Alcohol
VI. Precautions
- Routine use not recommended due to hepatotoxicity risk (see below)
- Avoid use longer than 24 weeks
- Discontinue at least 5 days before surgery
- May potentiate perioperative general Anesthesia
VII. Efficacy
- Mildly effective in Anxiety Disorder
VIII. Resources
- FDA Warning regarding Kava Hepatotoxicity
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Related Studies
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| SnomedCT | 412271007, 412231002 |
| English | kava, Kava, Kava Extract, KAVA, kava (medication), kava kava, Kava preparation, Kava kava, Kava extract (substance), Kava extract, Kava preparation (product), Piper Methysticum, KAVA EXTRACT |
| Spanish | extracto de kava (sustancia), extracto de kava, preparación con kava (producto), preparación con kava |
