Chondroitin

Aka: Chondroitin, Chondroitin sulfate

II. Indications

  1. Osteoarthritis (not recommended)

III. Mechanism

  1. Endogenous glycosaminoglycan contained in joint matrix

IV. Efficacy: Does not appear effective for Osteoarthritis

  1. Effect requires at least one month of therapy
  2. Recent large studies suggest that Chondroitin is not effective
    1. Initially appeared more effective than Placebo at relieving pain
    2. Adding Chondroitin to Glucosamine does not offer significant benefit
  3. References
    1. Reichenbach (2007) Ann Intern Med 146:580-90 [PubMed]

V. Source

  1. Animal sources such as shark and cow cartilage
    1. Theoretical risk of animal disease contamination

VI. Dosing

  1. Chondroitin 400 mg orally three time daily

VII. Adverse Effects

  1. Well tolerated
  2. Gastrointestinal upset

VIII. References

  1. Leeb (2000) J Rheumatol 27:205-11 [PubMed]
  2. McAlindon (2000) JAMA 283:1469-75 [PubMed]

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Related Studies

Ontology: Chondroitin (C0008454)

Definition (CSP) family of acetylgalactosamine mucopolysaccharides.
Definition (MSH) A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)
Concepts Biologically Active Substance (T123) , Carbohydrate (T118) , Pharmacologic Substance (T121)
MSH D002807
LNC LP21381-6
English chondroitin, CHONDROITIN, Chondroitin, Chondroitin [Chemical/Ingredient], chondroitins
Swedish Kondroitin
Czech chondroitin
Finnish Kondroitiini
Russian KHONDROITIN, ХОНДРОИТИН
Polish Chondroityna
Portuguese Condroitim, Condroitina
French Chondroïtine
German Chondroitin
Italian Condroitina
Spanish Condroitin
Derived from the NIH UMLS (Unified Medical Language System)

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