II. Medications: Prostaglandins

  1. Dinoprostone (PGE2 Gel, Cervidil, Prepidil)
    1. Available for oral, vaginal and sublingual use
  2. Misoprostol (PGE1, Cytotec)
    1. Available as vaginal preparation
  3. Adverse Effects
    1. Risk of tachysystole

III. Procedures: Mechanical Methods to Apply Pressure to Endocervix

  1. General
    1. Mechanism: Local pressure releases prostaglandins
    2. Risks
      1. Infection risk with Laminaria
      2. Artificial Rupture of Membranes
      3. Abruptio Placenta
      4. Cervical or uterine bleeding
  2. Hygroscopic Dilator (Laminaria, Lamicel)
    1. Dilator swells with absorption of local fluid
    2. Preparations
      1. Laminaria japonicum (Kelp, natural)
      2. Lamicel (synthetic)
    3. Technique
      1. Outpatient placement of dilator in endocervix
      2. Successive dilators placed until endocervix full
      3. No Fetal Heart Rate monitoring needed
  3. Balloon Dilator (e.g. 16 french Foley Catheter)
    1. Technique
      1. Catheter placed in endocervix
      2. Catheter tip inflated with 30 cc sterile water
      3. Traction applied to catheter
      4. Start Induction when catheter is extruded
    2. Adjuncts
      1. Weight end of catheter
      2. Tug on catheter 2-4 times per hour
      3. Sterile saline infusion
      4. Prostaglandin Gel
    3. Safety
      1. Does not appear to predispose to subsequent PTL
      2. Sciscione (2003) Am J Obstet Gynecol 190:751-4 [PubMed]
    4. Alternatives
      1. Foley Catheter placed intracervically and filled with 30-80 ml Normal Saline
  4. References
    1. de Vaan (2019) Cochrane Database Syst Rev (10): CD001233

IV. Non-Pharmacologic Methods

  1. Breast stimulation
    1. See Oxytocin Challenge Test
    2. Rigorous trials lacking to show benefit
    3. Theoretical benefit
      1. Breast stimulation stimulates Oxytocin release
      2. Fetal Heart Rate response similar to OCT
    4. Technique
      1. Gentle massage or warm compresses applied to Breast
      2. Done for one hour or repeated three times daily
  2. Sexual Intercourse
    1. Benefits in Cervical Ripening or induction unclear
    2. Theoretical benefit
      1. Female orgasm induces uterine contraction
      2. Semen contain prostaglandins
  3. Acupuncture or TENS unit
    1. Proposed for Oxytocin and prostaglandin release
    2. No rigorous studies to show benefit

V. Protocols: Alternative/Herbals

  1. General
    1. Used by some nurse-midwives in United States
    2. Anecdotal use in some cultures as long tradition
    3. No current rigorous studies on safety and efficacy
  2. Herbals historically used for Cervical Ripening
    1. Evening Primrose Oil
    2. Black Haw
    3. Black Cohosh
    4. Blue Cohosh
    5. Red raspberry leaves
  3. References
    1. McFarlin (1999) J Nurse Midwifery 44:205-16 [PubMed]

VI. Protocols: Disproved Methods that are not recommended

  1. Castor oil
  2. Hot baths
  3. Enemas

Images: Related links to external sites (from Bing)

Related Studies