II. Precautions

  1. Used only in Anesthesia, emergency and Intensive Care
  2. Airway and Respiratory Control is critical after use
  3. Paralytic Agents do not alter Level of Consciousness
    1. Must be used with sedation and analgesia

III. Indication

IV. Preparations

  1. Vecuronium 1 mg/ml after reconstituted with 10 ml saline or sterile water to 10 mg/10 ml

V. Mechanism

  1. Non-depolarizing Neuromuscular Blocking Agent
  2. Structurally similar to Pancuronium
    1. Same steroid nucleus
    2. Tertiary Nitrogen at position 2 is only difference
  3. Significantly different effects than Pancuronium
    1. Duration of action is half that of Pancuronium
    2. Hepatic excretion predominates
    3. Minimal cardiovascular effects

VI. Dose

  1. Initial Dose
    1. Vecuronium alone: 0.08 to 0.1 mg/kg IV
    2. Vecuronium after Succinylcholine: 0.04 to 0.06 mg/kg
  2. Maintenance dosing (if needed)
    1. Starts 25-40 minutes after initial dose
    2. Please see other references for maintenance dosing
  3. Reduce dosage in hepatic Impairment
  4. Do not use by intramuscular dosing

VII. Pharmacokinetics

  1. Onset: 1-2 minutes
  2. Maximal Neuromuscular Blockade by 3-5 minutes
  3. Duration: 30 minutes

VIII. References

  1. Miller in Katzung (1989) Pharmacology, p. 323-33
  2. Savarese in Miller (2000) Anesthesia, p. 412-90
  3. (2003) Lexicomp Drug database for Pocket PC

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Related Studies

Ontology: Vecuronium (C0242531)

Concepts Pharmacologic Substance (T121) , Steroid (T110)
MSH D014673
SnomedCT 372883002, 86085000
LNC LP62280-0
English VECURONIUM, vecuronium, Vecuronium (product), Vecuronium (substance), Vecuronium
Spanish vecuronio (producto), vecuronio (sustancia), vecuronio

Ontology: Norcuron (C0700018)

Concepts Pharmacologic Substance (T121) , Steroid (T110)
MSH D014673
English norcuron, Norcuron